Bisphosphonate-associated femoral fracture: implication for management

Studies carried out on individuals being treated longterm with bisphosphonates have provoked considerable interestand perplexity about the effect that these drugs have on boneturnover in the long run.In fact the experiences reported by numerous researcherstend to highlight how treatment with high doses of bisphosphonatesover many years, of individuals with osteoporosis complicatedby or secondary to neoplastic pathologies, causes asuppression of bone turnover that over time predisposes thebone to the accumulation of micro damage that can then resultin complicated fractures, as in the case described here.