Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a :3′,4′-c ]quinoxaline of pharmaceutical interest have been obtained by double site- and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono-adducts was obtained, at variance with literature reports. Specific studies to establish the exact stereochemistry of the bis-cycloadducts were undertaken.
|Numero di pagine||4|
|Stato di pubblicazione||Published - 2008|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry