Bis-1,2,4-triazolo[4,3-a:3',4'-c]quinoxalines of pharmaceutical interest from 1,3-dipolar cycloaddition

Annalisa Guarcello; Antonino Lauria; Anna Maria Almerico; Gaetano Dattolo

Bis-1,2,4-triazolo[4,3-a:3',4'-c]quinoxalines of pharmaceutical interest from 1,3-dipolar cycloaddition

Annalisa Guarcello, Antonino Lauria, Anna Maria Almerico, Gaetano Dattolo

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

15 Citazioni (Scopus)

Abstract

Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a :3′,4′-c ]quinoxaline of pharmaceutical interest have been obtained by double site- and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono-adducts was obtained, at variance with literature reports. Specific studies to establish the exact stereochemistry of the bis-cycloadducts were undertaken.

Lingua originale	English
pagine (da-a)	1847-1850
Numero di pagine	4
Rivista	Tetrahedron Letters
Volume	49
Stato di pubblicazione	Published - 2008

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Bis-1,2,4-triazolo[4,3-a:3',4'-c]quinoxalines of pharmaceutical interest from 1,3-dipolar cycloaddition",

abstract = "Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a :3′,4′-c ]quinoxaline of pharmaceutical interest have been obtained by double site- and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono-adducts was obtained, at variance with literature reports. Specific studies to establish the exact stereochemistry of the bis-cycloadducts were undertaken.",

keywords = "1, 3-dipolar cycloaddition; quinoxaline; nitrilimines, 1, 3-dipolar cycloaddition; quinoxaline; nitrilimines",

author = "Annalisa Guarcello and Antonino Lauria and Almerico, {Anna Maria} and Gaetano Dattolo",

year = "2008",

language = "English",

volume = "49",

pages = "1847--1850",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Bis-1,2,4-triazolo[4,3-a:3',4'-c]quinoxalines of pharmaceutical interest from 1,3-dipolar cycloaddition

AU - Guarcello, Annalisa

AU - Lauria, Antonino

AU - Almerico, Anna Maria

AU - Dattolo, Gaetano

PY - 2008

Y1 - 2008

N2 - Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a :3′,4′-c ]quinoxaline of pharmaceutical interest have been obtained by double site- and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono-adducts was obtained, at variance with literature reports. Specific studies to establish the exact stereochemistry of the bis-cycloadducts were undertaken.

AB - Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a :3′,4′-c ]quinoxaline of pharmaceutical interest have been obtained by double site- and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono-adducts was obtained, at variance with literature reports. Specific studies to establish the exact stereochemistry of the bis-cycloadducts were undertaken.

KW - 1

KW - 3-dipolar cycloaddition; quinoxaline; nitrilimines

KW - 1

KW - 3-dipolar cycloaddition; quinoxaline; nitrilimines

UR - http://hdl.handle.net/10447/43930

M3 - Article

VL - 49

SP - 1847

EP - 1850

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

ER -