TY - JOUR
T1 - Biomarkers of aging
AU - Rizzo, Claudia Maria
AU - Candore, Giuseppina
AU - Lio, Domenico
AU - Bulati, Matteo
AU - Caruso, Calogero
AU - Vasto, Sonya
AU - Colonna Romano, Giuseppina
AU - Nuzzo, Domenico
AU - Ferrara, Nicola
AU - Scapagnini, Giovanni
AU - Castiglia, Laura
AU - Pellicano', Mariavaleria
PY - 2010
Y1 - 2010
N2 - Aging is a complex process that negatively impacts the development of the different systems and its ability to function. Moreover, the Aging rate in humans is not the same, principally due to genetic heterogeneity and environmental factors. The aging rate is measured as the decline of functional capacity and stress resistance. Therefore, several attempts have been made to analyse the individual age, ( so-called biological age) compared to chronological age. The biomarkers of aging are age-related body function or composition, these markers aim to assess the biological age and predict the onset of age-related diseases and/or residual lifetime. Such biomarkers should help in one hand to characterise the biological age and on the other hand to identify individuals at high risk of developing age-associated diseases or disabilities. Unfortunately, most of the markers under discussion are related to age-related diseases rather than to age, so none of these markers discussed in literature is a true biomarker of aging. Hence, we discuss some disease-related biomarkers useful for a better understanding of aging and the development of new strategies to counteract it, essential for improving the quality of life of the elderly population.
AB - Aging is a complex process that negatively impacts the development of the different systems and its ability to function. Moreover, the Aging rate in humans is not the same, principally due to genetic heterogeneity and environmental factors. The aging rate is measured as the decline of functional capacity and stress resistance. Therefore, several attempts have been made to analyse the individual age, ( so-called biological age) compared to chronological age. The biomarkers of aging are age-related body function or composition, these markers aim to assess the biological age and predict the onset of age-related diseases and/or residual lifetime. Such biomarkers should help in one hand to characterise the biological age and on the other hand to identify individuals at high risk of developing age-associated diseases or disabilities. Unfortunately, most of the markers under discussion are related to age-related diseases rather than to age, so none of these markers discussed in literature is a true biomarker of aging. Hence, we discuss some disease-related biomarkers useful for a better understanding of aging and the development of new strategies to counteract it, essential for improving the quality of life of the elderly population.
KW - Aging
KW - Immunosenescence
KW - Inflammation
KW - biomarkers
KW - Aging
KW - Immunosenescence
KW - Inflammation
KW - biomarkers
UR - http://hdl.handle.net/10447/59547
M3 - Article
VL - 2
SP - 392
EP - 402
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
SN - 1093-9946
ER -