Biological properties of extracellular vesicles and their physiological functions

Francesco Cappello, Saara Laitinen, Mireia Olivan, Eva Rohde, Mateja Manček-Keber, Olivier De Wever, Eva Colás, Marina Rigau, An Hendrix, Maja Kosanovic, Katsutoshi Kokubun, Roman Stukelj, Zoraida Andreu, Cecilia Lässer, Veronika Kralj-Iglic, Susanne G. Van Der Grein, Peter Kierulf, Mario Gimona, Enriqueta Casal, Joana CarvalhoIrina Nazarenko, Georg Lipps, Jan Lötvall, Enriqueta Casal, Esther N.M. Nolte-'T Hoen, Mario Gimona, Apolonija Bedina Zavec, Thomas Lener, Juan M. Falcon-Perez, Pia R.-M. Siljander, Krisztina Buzas, Michael Graner, Bernd Giebel, Katharina Schallmoser, Anabela Cordeiro-Da Silva, María Yáñez-Mó, Marei Sammar, Maria Mittelbrunn, Irene M. Ghobrial, Lorraine O'Driscoll, Mayda Gursel, Éva Pállinger, Ihsan Gursel, Hernando A. Del Portillo, Francesc E. Borràs, Aija Line, Willem Stoorvogel, Niels H. H. Heegaard, Stefano Fais, Jaume Reventós, Edit I. Buzas, Antonio Marcilla, Alicia Llorente, Francesco Cappello, Tuula A. Nyman, Marca H. M. Wauben, M. Helena Helena Vasconcelos, Erzsébet Ligeti, Carla Oliveira, Francisco Sánchez-Madrid, Eva-Maria Krämer-Albers, Marie Stampe Ostenfeld, Santarém

Risultato della ricerca: Articlepeer review

1759 Citazioni (Scopus)

Abstract

In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells.While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
Lingua originaleEnglish
pagine (da-a)1-60
Numero di pagine60
RivistaJournal of Extracellular Vesicles
Volume4
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Histology
  • Cell Biology

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