Abstract

A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IRsignaling are involved in brain cognitive functions and their dysfunction isimplicated in Alzheimer’s disease (AD) neurodegeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim wehave designed, synthesized and characterized a nanogel system (NG) thathas been conjugated to insulin molecules (NG-In) to deliver the proteininto the brain, as a tool for the development of a new therapy against AD.In our preclinical study in mice, intraperitoneal injection of fluorescentlabeled NG has allowed to determine the biodistribution of NG vs time inthe whole body and its clearance through the kidneys and bladder. Furthermore, we have observed that mice injected with nanogel did not experiencestress, discomfort, nor mortalities have been recorded during the observationtime
Lingua originaleEnglish
Numero di pagine1
RivistaBiophysical Journal
Volume112
Stato di pubblicazionePublished - 2017

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Alzheimer Disease
Insulin
Therapeutics
Insulin Receptor
Brain
Intraperitoneal Injections
Cognition
Urinary Bladder
NanoGel
Kidney
Mortality

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title = "Biodistribution of Insulin-Nanogels in Mouse: A Preliminary Study for the Treatment of Alzheimer’s Disease",
abstract = "A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IRsignaling are involved in brain cognitive functions and their dysfunction isimplicated in Alzheimer’s disease (AD) neurodegeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim wehave designed, synthesized and characterized a nanogel system (NG) thathas been conjugated to insulin molecules (NG-In) to deliver the proteininto the brain, as a tool for the development of a new therapy against AD.In our preclinical study in mice, intraperitoneal injection of fluorescentlabeled NG has allowed to determine the biodistribution of NG vs time inthe whole body and its clearance through the kidneys and bladder. Furthermore, we have observed that mice injected with nanogel did not experiencestress, discomfort, nor mortalities have been recorded during the observationtime",
keywords = "Nanogels, Treatment of Alzheimer's Disease",
author = "Antonella Amato and Valeria Militello and Ditta, {Lorena Anna} and Laura Cristaldi and Flavia Mule' and Clelia Dispenza and Sabatino, {Maria Antonietta}",
year = "2017",
language = "English",
volume = "112",
journal = "Biophysical Journal",
issn = "0006-3495",
publisher = "Biophysical Society",

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TY - JOUR

T1 - Biodistribution of Insulin-Nanogels in Mouse: A Preliminary Study for the Treatment of Alzheimer’s Disease

AU - Amato, Antonella

AU - Militello, Valeria

AU - Ditta, Lorena Anna

AU - Cristaldi, Laura

AU - Mule', Flavia

AU - Dispenza, Clelia

AU - Sabatino, Maria Antonietta

PY - 2017

Y1 - 2017

N2 - A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IRsignaling are involved in brain cognitive functions and their dysfunction isimplicated in Alzheimer’s disease (AD) neurodegeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim wehave designed, synthesized and characterized a nanogel system (NG) thathas been conjugated to insulin molecules (NG-In) to deliver the proteininto the brain, as a tool for the development of a new therapy against AD.In our preclinical study in mice, intraperitoneal injection of fluorescentlabeled NG has allowed to determine the biodistribution of NG vs time inthe whole body and its clearance through the kidneys and bladder. Furthermore, we have observed that mice injected with nanogel did not experiencestress, discomfort, nor mortalities have been recorded during the observationtime

AB - A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IRsignaling are involved in brain cognitive functions and their dysfunction isimplicated in Alzheimer’s disease (AD) neurodegeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim wehave designed, synthesized and characterized a nanogel system (NG) thathas been conjugated to insulin molecules (NG-In) to deliver the proteininto the brain, as a tool for the development of a new therapy against AD.In our preclinical study in mice, intraperitoneal injection of fluorescentlabeled NG has allowed to determine the biodistribution of NG vs time inthe whole body and its clearance through the kidneys and bladder. Furthermore, we have observed that mice injected with nanogel did not experiencestress, discomfort, nor mortalities have been recorded during the observationtime

KW - Nanogels

KW - Treatment of Alzheimer's Disease

UR - http://hdl.handle.net/10447/247020

M3 - Meeting Abstract

VL - 112

JO - Biophysical Journal

JF - Biophysical Journal

SN - 0006-3495

ER -