TY - JOUR
T1 - Biodegradable hydrogels obtained by photocrosslinking of dextran and polyaspartamide derivatives
AU - Pitarresi, Giovanna
AU - Palumbo, Fabio Salvatore
AU - Giammona, Gaetano
AU - Casadei, Maria Antonietta
AU - Micheletti Moracci, null
PY - 2003
Y1 - 2003
N2 - The functionalization of dextran with glycidyl methacrylate (GMA) leads to the formation of a derivative that generates hydrogels for irradiation at 365nm. The effects of various polymer concentrations and irradiation times on the yield and the properties of the obtained hydrogels are reported. The networks have been characterized by FT-IR spectra, dimensional analysis and swelling measurements carried out at different pH values. In vitro studies suggest that all samples undergo a partial chemical hydrolysis, whereas the incubation with dextranases causes a total degradation whose rate depends on the degree of crosslinking. In addition, aqueous solutions of functionalized dextran have been irradiated in the presence of PHG (PHEA-GMA), i.e. the copolymer obtained by the reaction of α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) with GMA. The crosslinking reaction leads to the formation of new networks containing both polymers whose properties have been investigated. To evaluate the processes which occur during UV irradiation, the sol fractions have been purified and characterized by FT-IR and 1H-NMR analyses. Finally, the suitability of hydrogels deriving from functionalized dextran, crosslinked alone or in the presence of PHG, for drug delivery systems has been investigated choosing theophylline as a model drug. © 2003 Elsevier Science Ltd. All rights reserved.
AB - The functionalization of dextran with glycidyl methacrylate (GMA) leads to the formation of a derivative that generates hydrogels for irradiation at 365nm. The effects of various polymer concentrations and irradiation times on the yield and the properties of the obtained hydrogels are reported. The networks have been characterized by FT-IR spectra, dimensional analysis and swelling measurements carried out at different pH values. In vitro studies suggest that all samples undergo a partial chemical hydrolysis, whereas the incubation with dextranases causes a total degradation whose rate depends on the degree of crosslinking. In addition, aqueous solutions of functionalized dextran have been irradiated in the presence of PHG (PHEA-GMA), i.e. the copolymer obtained by the reaction of α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) with GMA. The crosslinking reaction leads to the formation of new networks containing both polymers whose properties have been investigated. To evaluate the processes which occur during UV irradiation, the sol fractions have been purified and characterized by FT-IR and 1H-NMR analyses. Finally, the suitability of hydrogels deriving from functionalized dextran, crosslinked alone or in the presence of PHG, for drug delivery systems has been investigated choosing theophylline as a model drug. © 2003 Elsevier Science Ltd. All rights reserved.
KW - α
KW - β-Poly(N-2-hydroxyethyl)-DL-aspartamide; Dextran; Drug release; Glycidyl methacrylate; Photocrosslinking; Biotechnology; Bioengineering; Biomedical Engineering
KW - α
KW - β-Poly(N-2-hydroxyethyl)-DL-aspartamide; Dextran; Drug release; Glycidyl methacrylate; Photocrosslinking; Biotechnology; Bioengineering; Biomedical Engineering
UR - http://hdl.handle.net/10447/207030
M3 - Article
VL - 24
SP - 4301
EP - 4313
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
ER -