Biocompatible PNIPAAM-halloysite nanotubes for thermo-responsive curcumin release

Risultato della ricerca: Article

59 Citazioni (Scopus)

Abstract

The grafting of poly(N-isopropylacrylamide) (PNIPAAM) onto the halloysite external surface is proposed in order to obtain a novel thermoresponsive drug carrier for curcumin delivery. The new nanomaterial is characterized by means of FT-IR spectroscopy, thermogravimetric analysis, and SEM investigations. A high density of polymer chain was achieved at the nanoparticle surface. The PNIPAAM dehydration phenomenon was observed in water above 32 °C that is nearly coincident with the lower critical solution temperature for the polymer. The colloidal stability as well as the wettability of the obtained nanomaterial may be triggered by temperature stimuli. In vitro tests simulating the gastrointestinal transit demonstrated that the proposed delivery system allows a targeted release of curcumin, preventing its degradation in an acidic medium. We synthesized a new hybrid nanoparticle that is very promising for several applications due to the copresence of a biocompatible region, to the temperature response, and to the hollow cavity, which can load active species.
Lingua originaleEnglish
pagine (da-a)8944-8951
Numero di pagine8
RivistaJOURNAL OF PHYSICAL CHEMISTRY. C
Stato di pubblicazionePublished - 2015

Fingerprint

Curcumin
Nanotubes
nanotubes
Nanostructured materials
delivery
Polymers
Nanoparticles
nanoparticles
Drug Carriers
polymers
transit
wettability
Dehydration
dehydration
stimuli
Temperature
temperature
Wetting
Thermogravimetric analysis
Infrared spectroscopy

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Physical and Theoretical Chemistry
  • Energy(all)

Cita questo

@article{b641240b370f4e6399510147a45650e5,
title = "Biocompatible PNIPAAM-halloysite nanotubes for thermo-responsive curcumin release",
abstract = "The grafting of poly(N-isopropylacrylamide) (PNIPAAM) onto the halloysite external surface is proposed in order to obtain a novel thermoresponsive drug carrier for curcumin delivery. The new nanomaterial is characterized by means of FT-IR spectroscopy, thermogravimetric analysis, and SEM investigations. A high density of polymer chain was achieved at the nanoparticle surface. The PNIPAAM dehydration phenomenon was observed in water above 32 °C that is nearly coincident with the lower critical solution temperature for the polymer. The colloidal stability as well as the wettability of the obtained nanomaterial may be triggered by temperature stimuli. In vitro tests simulating the gastrointestinal transit demonstrated that the proposed delivery system allows a targeted release of curcumin, preventing its degradation in an acidic medium. We synthesized a new hybrid nanoparticle that is very promising for several applications due to the copresence of a biocompatible region, to the temperature response, and to the hollow cavity, which can load active species.",
author = "Renato Noto and Stefana Milioto and Giuseppe Lazzara and Serena Riela and Giuseppe Cavallaro and Marina Massaro and Filippo Parisi",
year = "2015",
language = "English",
pages = "8944--8951",
journal = "Journal of Physical Chemistry C",
issn = "1932-7447",
publisher = "American Chemical Society",

}

TY - JOUR

T1 - Biocompatible PNIPAAM-halloysite nanotubes for thermo-responsive curcumin release

AU - Noto, Renato

AU - Milioto, Stefana

AU - Lazzara, Giuseppe

AU - Riela, Serena

AU - Cavallaro, Giuseppe

AU - Massaro, Marina

AU - Parisi, Filippo

PY - 2015

Y1 - 2015

N2 - The grafting of poly(N-isopropylacrylamide) (PNIPAAM) onto the halloysite external surface is proposed in order to obtain a novel thermoresponsive drug carrier for curcumin delivery. The new nanomaterial is characterized by means of FT-IR spectroscopy, thermogravimetric analysis, and SEM investigations. A high density of polymer chain was achieved at the nanoparticle surface. The PNIPAAM dehydration phenomenon was observed in water above 32 °C that is nearly coincident with the lower critical solution temperature for the polymer. The colloidal stability as well as the wettability of the obtained nanomaterial may be triggered by temperature stimuli. In vitro tests simulating the gastrointestinal transit demonstrated that the proposed delivery system allows a targeted release of curcumin, preventing its degradation in an acidic medium. We synthesized a new hybrid nanoparticle that is very promising for several applications due to the copresence of a biocompatible region, to the temperature response, and to the hollow cavity, which can load active species.

AB - The grafting of poly(N-isopropylacrylamide) (PNIPAAM) onto the halloysite external surface is proposed in order to obtain a novel thermoresponsive drug carrier for curcumin delivery. The new nanomaterial is characterized by means of FT-IR spectroscopy, thermogravimetric analysis, and SEM investigations. A high density of polymer chain was achieved at the nanoparticle surface. The PNIPAAM dehydration phenomenon was observed in water above 32 °C that is nearly coincident with the lower critical solution temperature for the polymer. The colloidal stability as well as the wettability of the obtained nanomaterial may be triggered by temperature stimuli. In vitro tests simulating the gastrointestinal transit demonstrated that the proposed delivery system allows a targeted release of curcumin, preventing its degradation in an acidic medium. We synthesized a new hybrid nanoparticle that is very promising for several applications due to the copresence of a biocompatible region, to the temperature response, and to the hollow cavity, which can load active species.

UR - http://hdl.handle.net/10447/180961

M3 - Article

SP - 8944

EP - 8951

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

SN - 1932-7447

ER -