Abstract
[3H]Flunitrazepam (FNZ) binding to cortical neurons from fetal rat brain was investigated in vitro. The use of a synthetic medium specific for neurons made it possible to plot a developmental curve of3H-FNZ binding in an almost pure neuronal culture. Detectable specific binding was present in vitro at time 0 (that is, the 16th gestational day). A progressive increase of binding, due to an increment in the number of recognition sites, was observed on the subsequent days. The affinity of the specific binding sites to3H-FNZ was enhanced by the addition of exogenous GABA, whereas the density was not affected. © 1990 Plenum Publishing Corporation.
Lingua originale | English |
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pagine (da-a) | 773-776 |
Numero di pagine | 4 |
Rivista | Neurochemical Research |
Volume | 15 |
Stato di pubblicazione | Published - 1990 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Cellular and Molecular Neuroscience