Binding equilibria between beta-cyclodextrin and p-nitro-aniline derivatives: the first systematic study in mixed water-methanol solvent systems.

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24 Citazioni (Scopus)

Abstract

Complexation equilibria, in mixed water-methanol solvent media, between native β-cyclodextrin and a set of suitably selected p-nitro-aniline derivatives were studied by means of polarimetry. The effects exerted by the organic co-solvent on the conditional inclusion free energies ΔGcond 0 and the differential molar optical rotations ΔΘ were thoroughly analyzed under the perspective of the enthalpy-entropy compensation effect. Experimental data suggest an intimate participation ('dynamic co-inclusion') of solvent molecules in the formation and in the conformational dynamics of the host-guest inclusion complex.
Lingua originaleEnglish
pagine (da-a)2037-2042
Numero di pagine6
RivistaTetrahedron
Volume65
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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