Complexation equilibria, in mixed water-methanol solvent media, between native β-cyclodextrin and a set of suitably selected p-nitro-aniline derivatives were studied by means of polarimetry. The effects exerted by the organic co-solvent on the conditional inclusion free energies ΔGcond 0 and the differential molar optical rotations ΔΘ were thoroughly analyzed under the perspective of the enthalpy-entropy compensation effect. Experimental data suggest an intimate participation ('dynamic co-inclusion') of solvent molecules in the formation and in the conformational dynamics of the host-guest inclusion complex.
|Numero di pagine||6|
|Stato di pubblicazione||Published - 2009|
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