Bi-layered polyurethane – Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model

Antonio D'Amore, Marcello Cammarata, Antonio D'Amore, Matthew T. Wolf, William R. Wagner, Tomo Yoshizumi, Samuel K. Luketich, Xinzhu Gu, Richard Hoff, Stephen F. Badylak

    Risultato della ricerca: Article

    42 Citazioni (Scopus)

    Abstract

    As an intervention to abrogate ischemic cardiomyopathy, the concept of applying a temporary, local patch to the surface of the recently infarcted ventricle has been explored from a number of design perspectives. Two important features considered for such a cardiac patch include the provision of appropriate mechanical support and the capacity to influence the remodeling pathway by providing cellular or biomolecule delivery. The objective of this report was to focus on these two features by first evaluating the incorporation of a cardiac extracellular matrix (ECM) component, and second by evaluating the impact of patch anisotropy on the pathological remodeling process initiated by myocardial infarction. The functional outcomes of microfibrous, elastomeric, biodegradable cardiac patches have been evaluated in a rat chronic infarction model. Ten weeks after infarction and 8 wk after patch epicardial placement, echocardiographic function, tissue-level structural remodeling (e.g., biaxial mechanical response and microstructural analysis), and cellular level remodeling were assessed. The results showed that the incorporation of a cardiac ECM altered the progression of several keys aspects of maladaptive remodeling following myocardial infarction. This included decreasing LV global mechanical compliance, inhibiting echocardiographically-measured functional deterioration, mitigating scar formation and LV wall thinning, and promoting angiogenesis. In evaluating the impact of patch anisotropy, no effects from the altered patch mechanics were detected after 8 wk, possibly due to patch fibrous encapsulation. Overall, this study demonstrates the benefit of a cardiac patch design that combines both ventricle mechanical support, through a biodegradable, fibrillary elastomeric component, and the incorporation of ECM-based hydrogel components.
    Lingua originaleEnglish
    pagine (da-a)1-14
    Numero di pagine14
    RivistaDefault journal
    Volume107
    Stato di pubblicazionePublished - 2016

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    Ventricular Remodeling
    Polyurethanes
    Extracellular Matrix
    Rats
    Anisotropy
    Infarction
    Myocardial Infarction
    Hydrogel
    Biomolecules
    Pathologic Processes
    Mechanics
    Cardiomyopathies
    Encapsulation
    Hydrogels
    Compliance
    Cicatrix
    Deterioration
    Tissue
    elastomeric

    All Science Journal Classification (ASJC) codes

    • Bioengineering
    • Ceramics and Composites
    • Biophysics
    • Biomaterials
    • Mechanics of Materials

    Cita questo

    Bi-layered polyurethane – Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model. / D'Amore, Antonio; Cammarata, Marcello; D'Amore, Antonio; Wolf, Matthew T.; Wagner, William R.; Yoshizumi, Tomo; Luketich, Samuel K.; Gu, Xinzhu; Hoff, Richard; Badylak, Stephen F.

    In: Default journal, Vol. 107, 2016, pag. 1-14.

    Risultato della ricerca: Article

    D'Amore, A, Cammarata, M, D'Amore, A, Wolf, MT, Wagner, WR, Yoshizumi, T, Luketich, SK, Gu, X, Hoff, R & Badylak, SF 2016, 'Bi-layered polyurethane – Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model', Default journal, vol. 107, pagg. 1-14.
    D'Amore, Antonio ; Cammarata, Marcello ; D'Amore, Antonio ; Wolf, Matthew T. ; Wagner, William R. ; Yoshizumi, Tomo ; Luketich, Samuel K. ; Gu, Xinzhu ; Hoff, Richard ; Badylak, Stephen F. / Bi-layered polyurethane – Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model. In: Default journal. 2016 ; Vol. 107. pagg. 1-14.
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    abstract = "As an intervention to abrogate ischemic cardiomyopathy, the concept of applying a temporary, local patch to the surface of the recently infarcted ventricle has been explored from a number of design perspectives. Two important features considered for such a cardiac patch include the provision of appropriate mechanical support and the capacity to influence the remodeling pathway by providing cellular or biomolecule delivery. The objective of this report was to focus on these two features by first evaluating the incorporation of a cardiac extracellular matrix (ECM) component, and second by evaluating the impact of patch anisotropy on the pathological remodeling process initiated by myocardial infarction. The functional outcomes of microfibrous, elastomeric, biodegradable cardiac patches have been evaluated in a rat chronic infarction model. Ten weeks after infarction and 8 wk after patch epicardial placement, echocardiographic function, tissue-level structural remodeling (e.g., biaxial mechanical response and microstructural analysis), and cellular level remodeling were assessed. The results showed that the incorporation of a cardiac ECM altered the progression of several keys aspects of maladaptive remodeling following myocardial infarction. This included decreasing LV global mechanical compliance, inhibiting echocardiographically-measured functional deterioration, mitigating scar formation and LV wall thinning, and promoting angiogenesis. In evaluating the impact of patch anisotropy, no effects from the altered patch mechanics were detected after 8 wk, possibly due to patch fibrous encapsulation. Overall, this study demonstrates the benefit of a cardiac patch design that combines both ventricle mechanical support, through a biodegradable, fibrillary elastomeric component, and the incorporation of ECM-based hydrogel components.",
    keywords = "Bioengineering, Biomaterials, Biophysics, Cardiac ECM, Cardiac patch, Ceramics and Composites, Electrospun scaffold, Mechanics of Materials, Structure - function",
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    T1 - Bi-layered polyurethane – Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model

    AU - D'Amore, Antonio

    AU - Cammarata, Marcello

    AU - D'Amore, Antonio

    AU - Wolf, Matthew T.

    AU - Wagner, William R.

    AU - Yoshizumi, Tomo

    AU - Luketich, Samuel K.

    AU - Gu, Xinzhu

    AU - Hoff, Richard

    AU - Badylak, Stephen F.

    PY - 2016

    Y1 - 2016

    N2 - As an intervention to abrogate ischemic cardiomyopathy, the concept of applying a temporary, local patch to the surface of the recently infarcted ventricle has been explored from a number of design perspectives. Two important features considered for such a cardiac patch include the provision of appropriate mechanical support and the capacity to influence the remodeling pathway by providing cellular or biomolecule delivery. The objective of this report was to focus on these two features by first evaluating the incorporation of a cardiac extracellular matrix (ECM) component, and second by evaluating the impact of patch anisotropy on the pathological remodeling process initiated by myocardial infarction. The functional outcomes of microfibrous, elastomeric, biodegradable cardiac patches have been evaluated in a rat chronic infarction model. Ten weeks after infarction and 8 wk after patch epicardial placement, echocardiographic function, tissue-level structural remodeling (e.g., biaxial mechanical response and microstructural analysis), and cellular level remodeling were assessed. The results showed that the incorporation of a cardiac ECM altered the progression of several keys aspects of maladaptive remodeling following myocardial infarction. This included decreasing LV global mechanical compliance, inhibiting echocardiographically-measured functional deterioration, mitigating scar formation and LV wall thinning, and promoting angiogenesis. In evaluating the impact of patch anisotropy, no effects from the altered patch mechanics were detected after 8 wk, possibly due to patch fibrous encapsulation. Overall, this study demonstrates the benefit of a cardiac patch design that combines both ventricle mechanical support, through a biodegradable, fibrillary elastomeric component, and the incorporation of ECM-based hydrogel components.

    AB - As an intervention to abrogate ischemic cardiomyopathy, the concept of applying a temporary, local patch to the surface of the recently infarcted ventricle has been explored from a number of design perspectives. Two important features considered for such a cardiac patch include the provision of appropriate mechanical support and the capacity to influence the remodeling pathway by providing cellular or biomolecule delivery. The objective of this report was to focus on these two features by first evaluating the incorporation of a cardiac extracellular matrix (ECM) component, and second by evaluating the impact of patch anisotropy on the pathological remodeling process initiated by myocardial infarction. The functional outcomes of microfibrous, elastomeric, biodegradable cardiac patches have been evaluated in a rat chronic infarction model. Ten weeks after infarction and 8 wk after patch epicardial placement, echocardiographic function, tissue-level structural remodeling (e.g., biaxial mechanical response and microstructural analysis), and cellular level remodeling were assessed. The results showed that the incorporation of a cardiac ECM altered the progression of several keys aspects of maladaptive remodeling following myocardial infarction. This included decreasing LV global mechanical compliance, inhibiting echocardiographically-measured functional deterioration, mitigating scar formation and LV wall thinning, and promoting angiogenesis. In evaluating the impact of patch anisotropy, no effects from the altered patch mechanics were detected after 8 wk, possibly due to patch fibrous encapsulation. Overall, this study demonstrates the benefit of a cardiac patch design that combines both ventricle mechanical support, through a biodegradable, fibrillary elastomeric component, and the incorporation of ECM-based hydrogel components.

    KW - Bioengineering

    KW - Biomaterials

    KW - Biophysics

    KW - Cardiac ECM

    KW - Cardiac patch

    KW - Ceramics and Composites

    KW - Electrospun scaffold

    KW - Mechanics of Materials

    KW - Structure - function

    UR - http://hdl.handle.net/10447/222129

    UR - http://www.journals.elsevier.com/biomaterials/

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