Beyond islet trasplantation in diabetes cell terapy:from embryonic stem cells to transdifferentation of adult cells

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4 Citazioni (Scopus)

Abstract

Exogenous insulin is, at the moment, the therapy of choice of diabetes, but does not allowtight regulation of glucose leading to long-term complications. Recently, pancreatic islettransplantation to reconstitute insulin-producing cells, has emerged as an alternativepromising therapeutic approach. Unfortunately, the number of donor islets is too lowcompared with the high number of patients needing a transplantation leading to a searchfor renewable sources of high-quality -cells. This review, summarizes more recentpromising approaches to the generation of new -cells from embryonic stem cells fortransdifferentiation of adult cells, particularly a critical examination of the seminal work byLumelsky et al.
Lingua originaleEnglish
pagine (da-a)2019-2024
Numero di pagine6
RivistaTransplantation Proceedings
Volume45
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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