Exogenous insulin is, at the moment, the therapy of choice of diabetes, but does not allowtight regulation of glucose leading to long-term complications. Recently, pancreatic islettransplantation to reconstitute insulin-producing cells, has emerged as an alternativepromising therapeutic approach. Unfortunately, the number of donor islets is too lowcompared with the high number of patients needing a transplantation leading to a searchfor renewable sources of high-quality -cells. This review, summarizes more recentpromising approaches to the generation of new -cells from embryonic stem cells fortransdifferentiation of adult cells, particularly a critical examination of the seminal work byLumelsky et al.
|Numero di pagine||6|
|Stato di pubblicazione||Published - 2013|
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