Benign myoclonic epilepsy in infancy: neuropsychological and behavioural outcome

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Benign myoclonic epilepsy in infancy (BMEI) is a rare syndrome of idiopathic generalized epilepsies with onset below 3 years of age. Ithas been reported that BMEI is associated with a good prognosis, however, recently some studies suggest less favourable neuropsychologicaloutcome. We report a long-term follow-up of seven patients with BMEI. Seizure outcome and neuropsychological, cognitive, andbehavioural evolution were discussed for each of them. At the end of follow-up, 86% of children showed neuropsychological and intellectualdisorders: two children had mental retardation, three patients achieved a borderline IQ and one normal but low IQ. All but one displayedneuropsychological disabilities including fine motor skill deficits, attention deficits, and language impairment and learning disorders. Ourclinical data and the previous reports suggest that the early onset of the seizures may be one of the main factors of the illness giving rise to aless favourable outcome. Additional interacting factors such as delayed start of treatment, and efficacy of the drugs may play an importantrole, too. We believe that BMEI does not exert, different from some epileptic encephalopathies, a quick destroying effect but may interferewith the growth of developing functions, which results in long-term neuropsychological disabilities.
Lingua originaleEnglish
pagine (da-a)218-223
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2800.2806???
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