Abstract

In the last years the neutrophil to lymphocyte ratio (NLR) has been examined in cardiovascular disorders and in particular in coronary artery disease and acute myocardial infarction (AMI). Now we examined this parameter in subjects with juvenile myocardial infarction at the initial stage and after 3 and 12 months. We enrolled 123 young subjects (112 men and 11 women, mean age 39.4±5.8 yrs) with AMI. The time interval between the AMI onset and the investigation was 13±7 days. The mean value of NLR observed in young AMI subjects was significantly increased compared to normal controls (N = 1.817±0.711; young AMI subjects = 2.376±0.873, p < 0.0001). NLR does not discriminate STEMI (2.427±0.878) and non STEMI (2.392±0.868) or diabetics (2.604±1.000) and non diabetics (2.324±0.853), but it differentiates smokers (2.276±0.853) and non smokers (2.837±1.072). NLR at the initial stage is not correlated with the number of cardiovascular risk factors or with the extent of the coronary disease. In this study we found a significant decrease of neutrophil count at 3 and 12 months later AMI without any significant variation of lymphocyte and consequently we observed a decrease in NLR at these two intervals of time in comparison with the initial stage. Despite some limitations present in this study, it is interesting to underline that also in juvenile myocardial infarction this low-cost haematological marker may be considered together with other inflammatory indicators.
Lingua originaleEnglish
pagine (da-a)239-247
Numero di pagine9
RivistaClinical Hemorheology and Microcirculation
Volume62
Stato di pubblicazionePublished - 2016

Fingerprint

Neutrophils
Myocardial Infarction
Lymphocytes
Coronary Disease
Coronary Artery Disease
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Physiology
  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cita questo

@article{04697efcd22448f89fa1816086a09bc2,
title = "Behaviour of the neutrophil to lymphocyte ratio in young subjects with acute myocardial infarction",
abstract = "In the last years the neutrophil to lymphocyte ratio (NLR) has been examined in cardiovascular disorders and in particular in coronary artery disease and acute myocardial infarction (AMI). Now we examined this parameter in subjects with juvenile myocardial infarction at the initial stage and after 3 and 12 months. We enrolled 123 young subjects (112 men and 11 women, mean age 39.4±5.8 yrs) with AMI. The time interval between the AMI onset and the investigation was 13±7 days. The mean value of NLR observed in young AMI subjects was significantly increased compared to normal controls (N = 1.817±0.711; young AMI subjects = 2.376±0.873, p < 0.0001). NLR does not discriminate STEMI (2.427±0.878) and non STEMI (2.392±0.868) or diabetics (2.604±1.000) and non diabetics (2.324±0.853), but it differentiates smokers (2.276±0.853) and non smokers (2.837±1.072). NLR at the initial stage is not correlated with the number of cardiovascular risk factors or with the extent of the coronary disease. In this study we found a significant decrease of neutrophil count at 3 and 12 months later AMI without any significant variation of lymphocyte and consequently we observed a decrease in NLR at these two intervals of time in comparison with the initial stage. Despite some limitations present in this study, it is interesting to underline that also in juvenile myocardial infarction this low-cost haematological marker may be considered together with other inflammatory indicators.",
author = "Baldassare Canino and Gregorio Caimi and {Lo Presti}, Rosalia and Eugenia Hopps and Eleonora Ferrera",
year = "2016",
language = "English",
volume = "62",
pages = "239--247",
journal = "Clinical Hemorheology and Microcirculation",
issn = "1386-0291",
publisher = "IOS Press",

}

TY - JOUR

T1 - Behaviour of the neutrophil to lymphocyte ratio in young subjects with acute myocardial infarction

AU - Canino, Baldassare

AU - Caimi, Gregorio

AU - Lo Presti, Rosalia

AU - Hopps, Eugenia

AU - Ferrera, Eleonora

PY - 2016

Y1 - 2016

N2 - In the last years the neutrophil to lymphocyte ratio (NLR) has been examined in cardiovascular disorders and in particular in coronary artery disease and acute myocardial infarction (AMI). Now we examined this parameter in subjects with juvenile myocardial infarction at the initial stage and after 3 and 12 months. We enrolled 123 young subjects (112 men and 11 women, mean age 39.4±5.8 yrs) with AMI. The time interval between the AMI onset and the investigation was 13±7 days. The mean value of NLR observed in young AMI subjects was significantly increased compared to normal controls (N = 1.817±0.711; young AMI subjects = 2.376±0.873, p < 0.0001). NLR does not discriminate STEMI (2.427±0.878) and non STEMI (2.392±0.868) or diabetics (2.604±1.000) and non diabetics (2.324±0.853), but it differentiates smokers (2.276±0.853) and non smokers (2.837±1.072). NLR at the initial stage is not correlated with the number of cardiovascular risk factors or with the extent of the coronary disease. In this study we found a significant decrease of neutrophil count at 3 and 12 months later AMI without any significant variation of lymphocyte and consequently we observed a decrease in NLR at these two intervals of time in comparison with the initial stage. Despite some limitations present in this study, it is interesting to underline that also in juvenile myocardial infarction this low-cost haematological marker may be considered together with other inflammatory indicators.

AB - In the last years the neutrophil to lymphocyte ratio (NLR) has been examined in cardiovascular disorders and in particular in coronary artery disease and acute myocardial infarction (AMI). Now we examined this parameter in subjects with juvenile myocardial infarction at the initial stage and after 3 and 12 months. We enrolled 123 young subjects (112 men and 11 women, mean age 39.4±5.8 yrs) with AMI. The time interval between the AMI onset and the investigation was 13±7 days. The mean value of NLR observed in young AMI subjects was significantly increased compared to normal controls (N = 1.817±0.711; young AMI subjects = 2.376±0.873, p < 0.0001). NLR does not discriminate STEMI (2.427±0.878) and non STEMI (2.392±0.868) or diabetics (2.604±1.000) and non diabetics (2.324±0.853), but it differentiates smokers (2.276±0.853) and non smokers (2.837±1.072). NLR at the initial stage is not correlated with the number of cardiovascular risk factors or with the extent of the coronary disease. In this study we found a significant decrease of neutrophil count at 3 and 12 months later AMI without any significant variation of lymphocyte and consequently we observed a decrease in NLR at these two intervals of time in comparison with the initial stage. Despite some limitations present in this study, it is interesting to underline that also in juvenile myocardial infarction this low-cost haematological marker may be considered together with other inflammatory indicators.

UR - http://hdl.handle.net/10447/237073

UR - http://iospress.metapress.com/content/103148

M3 - Article

VL - 62

SP - 239

EP - 247

JO - Clinical Hemorheology and Microcirculation

JF - Clinical Hemorheology and Microcirculation

SN - 1386-0291

ER -