Aim: The transgenic D1CT-7 mouse is one of the best-characterized animal models of Tourette's syndrome (TS), exhibiting spontaneous tic-like Head-Body Twitches (HBT) and deficits in sensorimotor gating. This study is aimed at evaluating the behavioral dynamics of these mutants and their potential relevance to TS. Methods: The behavior of D1CT-7 and Wild Type littermates was firstly assessed by considering frequencies and durations. To detect recurrent real-time behavioral sequences, the multivariate T-pattern analysis was employed. Analyses of transition probabilities among behaviors further provided an overall picture of the behavioral dynamics. Results: T-patterns and transition matrices revealed in D1CT-7 mice a clear-cut hyperactivity compared to controls, with a lower behavioral organization and a marked shift from cautious sniffing toward locomotion. Moreover, the behavioral patterns of the transgenic mice were pervasively disturbed by intrusive tic-like HBT leading to a marked fragmentation of the behavior. Novel exposure to open field provoked a transient inhibitory control over the disrupting phenotype. Conclusion: The results of this study show that the D1CT-7 mouse model is subjected to a behavioral fragmentation, with repercussions going beyond the simple tic-like phenomenon. These phenotypes are strikingly akin to behavioral problems observed in patients with TS and further validate the power of this model in summarizing pivotal behavioral aspects of TS.
|Numero di pagine||9|
|Rivista||CNS NEUROSCIENCE & THERAPEUTICS|
|Stato di pubblicazione||Published - 2018|
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Physiology (medical)
- Pharmacology (medical)
Crescimanno, G., Casarrubea, M., Santangelo, A., Mosher, L. J., Cassioli, E., Bortolato, M., Di Giovanni, G., & Ricca, V. (2018). Behavioral fragmentation in the D1CT-7 mouse model of Tourette's syndrome. CNS NEUROSCIENCE & THERAPEUTICS, 24, 703-711.