Abstract
A series of 66 cases of oral squamous cell carcinoma (OSCC) was retrospectively analyzed by immunohistochemistry for bcl-2 expression to verify its predictive value for clinical outcome in patients with OSCC. After grouping for bcl-2 expression, OSCCs were statistically analyzed for the variables age, gender, histological grading (G), TNM, staging, recurrence, and overall survival rate. Univariate and multivariate (Cox regression) analyses were performed. Thirty-six OSCC (54.5%) showed expression for bcl-2, whereas 30 (44.5%) were negative. No statistical association was found between bcl-2 expression and any variables considered at baseline. Overall disease-specific survival rate at 72 months was 51%, independently from the extent of the tumor. In terms of prognostic significance, the bcl-2-positive group showed more than 60% survival at 72 months whereas the bcl-2-negative group showed none. An independent association of bcl-2 expression was found with an improved overall survival rate (p = 0.048), although grading and staging were established to be the best baseline markers of prognosis. On the basis of these results, it is possible to suggest bcl-2 as an early marker of prognosis: lack of bcl-2 expression could constitute a hallmark of aggressive biological behavior in OSCC.
Lingua originale | English |
---|---|
pagine (da-a) | 249-255 |
Numero di pagine | 7 |
Rivista | Oncology Research |
Volume | 15 |
Stato di pubblicazione | Published - 2005 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.2700.2730???
- ???subjectarea.asjc.1300.1306???