Bacterial–viral load and the immune response in stable and exacerbated COPD: Significance and therapeutic prospects

Francesco Cappello, Antonino Di Stefano, Silvestro Ennio D’Anna, Bruno Balbi, Mauro Carone, Francesco Cappello, Silvestro Ennio D’Anna

Risultato della ricerca: Article

16 Citazioni (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and an abnormal inflammatory response of the lung. Bacteria and viruses are a major cause of COPD exacerbations and may contribute to COPD progression by perpetuating the inflammatory response in the airways. Bacterial variety diminishes with increasing COPD severity. Respiratory viruses can colonize the lower respiratory tract in stable COPD, altering the respiratory microbiome and facilitating secondary bacterial infections. In this review, we present the most updated information about the role of bacteria and viruses in stable and exacerbated COPD. In our opinion, to optimize therapeutic strategies, the dynamic events involving bacterial–viral infections and related immune response in COPD phenotypes need to be better clarified. Our paper would address these points that we consider of great importance for the clinical management of COPD.
Lingua originaleEnglish
pagine (da-a)445-453
Numero di pagine9
RivistaINTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Volume11
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Pulmonary and Respiratory Medicine

Fingerprint Entra nei temi di ricerca di 'Bacterial–viral load and the immune response in stable and exacerbated COPD: Significance and therapeutic prospects'. Insieme formano una fingerprint unica.

  • Cita questo