Bacterial biofilms: a challenge in the discovery of new anti-infective agents.

Risultato della ricerca: Other

Abstract

The ability to form a biofilm, bacterialcommunities able to grow on surfaces andsurrounded by an extracellular polymeric substance biofilm agents.Our research group focused on discovering of novelchemical agents of potential therapeutic utility in the treatment of staphylococcal biofilm-associatedinfections by screening novel compounds (syntheticor natural). In a recent study, the antistaphylococcalbiofilm activity of pyrrolomycins C,D, F1, F2a, F2b, F3 a family of halogenated pyrroles which are naturally produced byActinosporangium vitaminophylum and of the synthesized related compounds I, II, III were investigated and compared (Schillaci et al, 2010).We also focused on marine invertebrates as source of new antibiofilm agents and the activity of the 5kDa peptide fraction of the cytosol from coelomocytes of Paracentrotus lividus (sea-urchin) against staphylococcal biofilms was determined
Lingua originaleEnglish
Pagine6-7
Numero di pagine2
Stato di pubblicazionePublished - 2010

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Biofilms
Anti-Infective Agents
Pyrroles
Screening
Peptides

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N2 - The ability to form a biofilm, bacterialcommunities able to grow on surfaces andsurrounded by an extracellular polymeric substance biofilm agents.Our research group focused on discovering of novelchemical agents of potential therapeutic utility in the treatment of staphylococcal biofilm-associatedinfections by screening novel compounds (syntheticor natural). In a recent study, the antistaphylococcalbiofilm activity of pyrrolomycins C,D, F1, F2a, F2b, F3 a family of halogenated pyrroles which are naturally produced byActinosporangium vitaminophylum and of the synthesized related compounds I, II, III were investigated and compared (Schillaci et al, 2010).We also focused on marine invertebrates as source of new antibiofilm agents and the activity of the 5kDa peptide fraction of the cytosol from coelomocytes of Paracentrotus lividus (sea-urchin) against staphylococcal biofilms was determined

AB - The ability to form a biofilm, bacterialcommunities able to grow on surfaces andsurrounded by an extracellular polymeric substance biofilm agents.Our research group focused on discovering of novelchemical agents of potential therapeutic utility in the treatment of staphylococcal biofilm-associatedinfections by screening novel compounds (syntheticor natural). In a recent study, the antistaphylococcalbiofilm activity of pyrrolomycins C,D, F1, F2a, F2b, F3 a family of halogenated pyrroles which are naturally produced byActinosporangium vitaminophylum and of the synthesized related compounds I, II, III were investigated and compared (Schillaci et al, 2010).We also focused on marine invertebrates as source of new antibiofilm agents and the activity of the 5kDa peptide fraction of the cytosol from coelomocytes of Paracentrotus lividus (sea-urchin) against staphylococcal biofilms was determined

KW - antimicrobial peptides

KW - antimicrobials

KW - staphylococcal biofilms

UR - http://hdl.handle.net/10447/55485

M3 - Other

SP - 6

EP - 7

ER -