B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans.

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Abstract

Immunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy elderly.
Lingua originaleEnglish
pagine (da-a)274-284
Numero di pagine11
RivistaAgeing Research Reviews
Volume10
Stato di pubblicazionePublished - 2011

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Immunoglobulin D
B-Lymphocytes
Immunoglobulin G
Cells
Data storage equipment
Antigens
T-cells
Immune system
B-Lymphocyte Subsets
Aptitude
Immune System
Vaccination
T-Lymphocytes
Immunosenescence

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Neurology
  • Molecular Biology
  • Ageing
  • Biochemistry

Cita questo

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title = "B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans.",
abstract = "Immunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy elderly.",
keywords = "B cells, elderly",
author = "Calogero Caruso and {Colonna Romano}, Giuseppina and Giuseppina Candore and Matteo Bulati and Mariavaleria Pellicano' and Silvio Buffa and Dunn-Walters, {Deborah K.} and Yu-Chang Wu",
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pages = "274--284",
journal = "Ageing Research Reviews",
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T1 - B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans.

AU - Caruso, Calogero

AU - Colonna Romano, Giuseppina

AU - Candore, Giuseppina

AU - Bulati, Matteo

AU - Pellicano', Mariavaleria

AU - Buffa, Silvio

AU - Dunn-Walters, Deborah K.

AU - Wu, Yu-Chang

PY - 2011

Y1 - 2011

N2 - Immunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy elderly.

AB - Immunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy elderly.

KW - B cells, elderly

UR - http://hdl.handle.net/10447/66209

M3 - Article

VL - 10

SP - 274

EP - 284

JO - Ageing Research Reviews

JF - Ageing Research Reviews

SN - 1568-1637

ER -