B cell immunosenescence: different features of naive and memory B cells in elderly

Giuseppina Colonna Romano, Matteo Bulati, Calogero Caruso, Giuseppina Candore, Salvatore Vitello, Mariavaleria Pellicanó, Yu-Chang Wu, Deborah K. Dunn-Walters, Silvio Buffa, Mariavaleria Pellicano'

Risultato della ricerca: Articlepeer review

60 Citazioni (Scopus)


Elderly people show a reduced protection against new infections and a decreased response to vaccines as a consequence of impairment of both cellular and humoral immunity. In this paper we have studied memory/naïve B cells in the elderly, evaluating surface immunoglobulin expression, production of the pro- and anti-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-10, and presence of somatic hypermutation, focusing on the IgG(+)IgD(-)CD27(-) double negative (DN) B cells that are expanded in the elderly. Our results show that naïve B cells from young donors need a sufficiently strong stimulus to be activated "in vitro", while naïve B cells from old subjects are able to produce IL-10 and TNF-α when stimulated "physiologically" (α-CD40/IL-4), suggesting that these cells might play a role in the control of the immuno-inflammatory environment in the elderly. In addition, in the elderly there is an accumulation of DN B cells with a reduced rate of somatic hypermutation. Thus, DN B lymphocytes may be exhausted cells that are expanded and accumulate as a by-product of persistent stimulation or impaired germinal center formation
Lingua originaleEnglish
pagine (da-a)473-483
Numero di pagine11
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2900.2909???
  • ???subjectarea.asjc.2700.2717???


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