Autoimmune liver disease in a sicilian woman.

Giovam Battista Rini, Angelo Maria Patti, Pasquale Mansueto, Alberto D'Alcamo, Aurelio Seidita, Floriana Adragna

Risultato della ricerca: Articlepeer review

Abstract

Autoimmune hepatitis (AIH) is a chronic liver disease characterized by clinical features analogue to viral and non-autoimmuneliver disorders, but with distinct sero-autoimmunologic properties. The disease results from a network of complex interactionsinvolving genetic predisposition, triggering factors, autoantigens and immunoregulatory system. Diagnosis of AIH relies on positiveautoantibodies determination and on liver core biopsy histological appearance. Corticosteroid and immunosuppressive drugs are generally useful in the treatment of disease. However, when inflammation cannot be controlled, progression from chronic hepatitis to cirrhosis is often observed and hepatocellular carcinoma may appear at the end stage. Here we reported a case of a woman, affectedwith AIH. The patient presented features of chronic liver disease of neither viral nor alcoholic aetiology. Serum evidence of hypertraminasemia, hypergammaglobulinemia and specific autoantibodies were the leading points to final diagnosis, which was validatedby liver biopsy. The patient was, finally, successfully treated with steroids.
Lingua originaleEnglish
pagine (da-a)13-18
Numero di pagine6
RivistaActa Medica Mediterranea
Volume28
Stato di pubblicazionePublished - 2012

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