Kabuki syndrome (KS) (Kabuki make-up syndrome, Niikawa-Kuroki syndrome) is a rare genetic disorder first diagnosed in 1981.Kabuki make-up syndrome (KMS) is a multiple malformation/intellectual disability syndrome that was first described in Japan but is now reported in many other ethnic groups.KMS is characterized by multiple congenital abnormalities: craniofacial, skeletal, and dermatoglyphic abnormalities; intellectual disability; and short stature. Other findings may include: congenital heart defects, genitourinaryanomalies, cleft lip and/or palate, gastrointestinal anomalies including analatresia, ptosis and strabismus, and widely spaced teeth and hypodontia. The KS is associated with mutations in the MLL2 gene in some cases were also observed deletions of KDM6A. This study describes three childrenwith autism spectrum disorders (ASDs) and KS and rehabilitative intervention that must be implemented.
|Numero di pagine||7|
|Stato di pubblicazione||Published - 2015|
All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health