Aulogous fibrin sealant (Vivostat®) in the neurosurgical practice: Part II: Vertebro-spinal procedures

Domenico Iacopino, Rosario Maugeri, Francesca Graziano, Favia Meccio, Luigi Basile, Domenico Gerardo Iacopino, Flavia Meccio

Risultato della ricerca: Articlepeer review

34 Citazioni (Scopus)


Background: Epidural hematomas, cerebrospinal fluid fistula, and spinal infections are challenging postoperative complications following vertebro-spinal procedures. We report our preliminary results using autologous fibrin sealant as both fibrin glue and a hemostatic during these operations. Methods: Prospectively, between January 2013 and March 2015, 68 patients received an autologous fibrin sealant prepared with the Vivostat®system applied epidurally to provide hemostasis and to seal the dura. The surgical technique, time to bleeding control, and associated complications were recorded. Results: Spinal procedures were performed in 68 patients utilizing autologous fibrin glue/Vivostat®to provide rapid hemostasis and/or to seal the dura. Only 2 patients developed postoperative dural fistulas while none exhibited hemorrhages, allergic reactions, systemic complications, or infections. Conclusions: In this preliminary study, the application of autologous fibrin sealant with Vivostat®resulted in rapid hemostasis and/or acted as an effective dural sealant. Although this product appears to be safe and effective, further investigations are warranted.
Lingua originaleEnglish
pagine (da-a)S77-S82
Numero di pagine5
RivistaSurgical Neurology International
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

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