Atractyligenin chemistry. Part 4: Synthesis of the 15β-ol epimer of atractyligenin

Lorenzo Camarda, Vita Di Stefano, Leopoldo Ceraulo, Mirella Ferrugia, Camarda, Mirella Ferrugia, Vita Di Stefano, Leopoldo Ceraulo

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Abstract

The oxidation with PCC of atractyligenin 3, the aglicone of the toxic glycoside 1 isolated from Atractylis gummifera L., led to the 15-oxo-derivative 6, together with a small amount of 2,15-dioxoderivative 5, with a selective oxidation of the allylic 15-OH group of the molecule. Further reduction with NaBH4 and KOH hydrolysis gave stereoselectively the 15β-ol epimer of atractiligenin 9.
Lingua originaleEnglish
pagine (da-a)189-191
Numero di pagine3
RivistaBollettino Chimico Farmaceutico
Volume135
Stato di pubblicazionePublished - 1996

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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