Atractyligenin chemistry. Part 4: Synthesis of the 15β-ol epimer of atractyligenin

Lorenzo Camarda; Vita Di Stefano; Leopoldo Ceraulo; Mirella Ferrugia; null Camarda; Mirella Ferrugia; Vita Di Stefano; Leopoldo Ceraulo

Atractyligenin chemistry. Part 4: Synthesis of the 15β-ol epimer of atractyligenin

Lorenzo Camarda, Vita Di Stefano, Leopoldo Ceraulo, Mirella Ferrugia, Camarda, Mirella Ferrugia, Vita Di Stefano, Leopoldo Ceraulo

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

Abstract

The oxidation with PCC of atractyligenin 3, the aglicone of the toxic glycoside 1 isolated from Atractylis gummifera L., led to the 15-oxo-derivative 6, together with a small amount of 2,15-dioxoderivative 5, with a selective oxidation of the allylic 15-OH group of the molecule. Further reduction with NaBH4 and KOH hydrolysis gave stereoselectively the 15β-ol epimer of atractiligenin 9.

Lingua originale	English
pagine (da-a)	189-191
Numero di pagine	3
Rivista	Bollettino Chimico Farmaceutico
Volume	135
Stato di pubblicazione	Published - 1996

All Science Journal Classification (ASJC) codes

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title = "Atractyligenin chemistry. Part 4: Synthesis of the 15β-ol epimer of atractyligenin",

abstract = "The oxidation with PCC of atractyligenin 3, the aglicone of the toxic glycoside 1 isolated from Atractylis gummifera L., led to the 15-oxo-derivative 6, together with a small amount of 2,15-dioxoderivative 5, with a selective oxidation of the allylic 15-OH group of the molecule. Further reduction with NaBH4 and KOH hydrolysis gave stereoselectively the 15β-ol epimer of atractiligenin 9.",

author = "Lorenzo Camarda and {Di Stefano}, Vita and Leopoldo Ceraulo and Mirella Ferrugia and Camarda and Mirella Ferrugia and {Di Stefano}, Vita and Leopoldo Ceraulo",

year = "1996",

language = "English",

volume = "135",

pages = "189--191",

journal = "Bollettino Chimico Farmaceutico",

issn = "0006-6648",

publisher = "Societa Editoriale Farmaceutica",

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TY - JOUR

T1 - Atractyligenin chemistry. Part 4: Synthesis of the 15β-ol epimer of atractyligenin

AU - Camarda, Lorenzo

AU - Di Stefano, Vita

AU - Ceraulo, Leopoldo

AU - Ferrugia, Mirella

AU - Camarda, null

AU - Ferrugia, Mirella

AU - Di Stefano, Vita

AU - Ceraulo, Leopoldo

PY - 1996

Y1 - 1996

N2 - The oxidation with PCC of atractyligenin 3, the aglicone of the toxic glycoside 1 isolated from Atractylis gummifera L., led to the 15-oxo-derivative 6, together with a small amount of 2,15-dioxoderivative 5, with a selective oxidation of the allylic 15-OH group of the molecule. Further reduction with NaBH4 and KOH hydrolysis gave stereoselectively the 15β-ol epimer of atractiligenin 9.

AB - The oxidation with PCC of atractyligenin 3, the aglicone of the toxic glycoside 1 isolated from Atractylis gummifera L., led to the 15-oxo-derivative 6, together with a small amount of 2,15-dioxoderivative 5, with a selective oxidation of the allylic 15-OH group of the molecule. Further reduction with NaBH4 and KOH hydrolysis gave stereoselectively the 15β-ol epimer of atractiligenin 9.

UR - http://hdl.handle.net/10447/445406

M3 - Article

SN - 0006-6648

VL - 135

SP - 189

EP - 191

JO - Bollettino Chimico Farmaceutico

JF - Bollettino Chimico Farmaceutico

ER -

Atractyligenin chemistry. Part 4: Synthesis of the 15β-ol epimer of atractyligenin

Abstract

All Science Journal Classification (ASJC) codes

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