Atorvastatin in stable angina patients lowers CCL2 and ICAM1 expression: Pleiotropic evidence from plasma mRNA analyses.

Manfredi Rizzo, Snezana Uletilovic, Katja Lakota, Andrej Artenjak, Ljubomir Sormaz, Darja Stojanovic, Snezna Sodin-Semrl, Bosa Mirjanic-Azaric, Darko Cerne, Janja Marc

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Objective: Statin pleiotropy is still an evolving concept, and the lack of clarity on this subject is due atleast in part to the lack of a definitive biomarker for statin pleiotropy. Using plasma mRNA analysis as anovel research tool for the non-invasive in vivo assessment of gene expression in vascular beds, wehypothesised that atorvastatin lowers the plasmamRNA level from statin pleiotropy-target genes, and the reductionis independent of the reduction of low-density lipoprotein cholesterol (LDL-C).Design and methods: Forty-four patients with stable angina received atorvastatin therapy (20 mg/day,10 weeks). Plasma chemokine (C-C motif) ligand 2 (CCL2) and intercellular adhesion molecule-1 (ICAM1)mRNA levels and their protein concentrations (MCP-1, sICAM-1) were analysed before and after the treatment.Plasma vascular adhesion molecule-1 (sVCAM-1) concentrations were also analysed.Results: Atorvastatin lowered plasma mRNA levels (CCL2: −31.76%, p = 0.037; ICAM1: −34.09%,p b 0.001) and MCP-1 protein concentration (−18.88%, p = 0.008) but did not lower sICAM-1 andsVCAM-1 protein concentrations, and the decreases appeared to be independent from the lowering ofLDL-C. The plasma mRNA levels correlated with their protein concentrations following statin treatment only.Conclusion: Our results significantly strengthen the clinical evidence in support of statin pleiotropy. Furthermore,this unique simultaneous measurement of plasma mRNAs and their protein concentrations offersan advanced non-invasive in vivo assessment of the circulation pathology
Lingua originaleEnglish
pagine (da-a)1526-1531
Numero di pagine6
RivistaClinical Biomechanics
Volume46
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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