Abstract

Coronary heart disease is the single most common cause of illness and death in the developed world. Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and plaque disruption with superimposed thrombosis is the main cause of the acute coronary syndromes of unstable angina, myocardial infarction, and sudden death. Atherosclerosis is the result of a complex interaction between blood elements, disturbed flow, and vessel wall abnormality, involving several pathological processes: inflammation, with increased endothelial permeability, endothelial activation, and monocyte recruitment; growth, with smooth muscle cell proliferation, migration, and matrix synthesis; degeneration, with lipid accumulation; necrosis, possibly related to the cytotoxic effect of oxidized lipid; calcification/ossification, which may represent an active rather than a dystrophic process; and thrombosis, with platelet recruitment and fibrin formation. In this review we discuss these processes and the possible pathological effects of Chlamydia infection and the ensuing phlogosis.
Lingua originaleEnglish
pagine (da-a)31-40
Numero di pagine10
RivistaWorld Journal of Cardiology
Volume1
Stato di pubblicazionePublished - 2009

Fingerprint

Chlamydophila pneumoniae
Pathologic Processes
Atherosclerosis
Thrombosis
Inflammation
Lipids
Chlamydia Infections
Unstable Angina
Acute Coronary Syndrome
Sudden Death
Fibrin
Osteogenesis
Smooth Muscle Myocytes
Cell Movement
Myocardial Ischemia
Coronary Disease
Coronary Artery Disease
Monocytes
Cause of Death
Permeability

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cita questo

@article{d1c50aa7e4be4c2cb26c8298b1dbf464,
title = "Atherosclerosis, inflammation and Chlamydia pneumoniae.",
abstract = "Coronary heart disease is the single most common cause of illness and death in the developed world. Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and plaque disruption with superimposed thrombosis is the main cause of the acute coronary syndromes of unstable angina, myocardial infarction, and sudden death. Atherosclerosis is the result of a complex interaction between blood elements, disturbed flow, and vessel wall abnormality, involving several pathological processes: inflammation, with increased endothelial permeability, endothelial activation, and monocyte recruitment; growth, with smooth muscle cell proliferation, migration, and matrix synthesis; degeneration, with lipid accumulation; necrosis, possibly related to the cytotoxic effect of oxidized lipid; calcification/ossification, which may represent an active rather than a dystrophic process; and thrombosis, with platelet recruitment and fibrin formation. In this review we discuss these processes and the possible pathological effects of Chlamydia infection and the ensuing phlogosis.",
keywords = "ATHEROSCLEROSIS, INFECTION",
author = "Salvatore Novo and Giuseppina Novo and Alessandro Gullotti and Giovanni Fazio and Maria Giovino and Daniela Bacarella",
year = "2009",
language = "English",
volume = "1",
pages = "31--40",
journal = "World Journal of Cardiology",
issn = "1949-8462",
publisher = "Baishideng Publishing Group",

}

TY - JOUR

T1 - Atherosclerosis, inflammation and Chlamydia pneumoniae.

AU - Novo, Salvatore

AU - Novo, Giuseppina

AU - Gullotti, Alessandro

AU - Fazio, Giovanni

AU - Giovino, Maria

AU - Bacarella, Daniela

PY - 2009

Y1 - 2009

N2 - Coronary heart disease is the single most common cause of illness and death in the developed world. Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and plaque disruption with superimposed thrombosis is the main cause of the acute coronary syndromes of unstable angina, myocardial infarction, and sudden death. Atherosclerosis is the result of a complex interaction between blood elements, disturbed flow, and vessel wall abnormality, involving several pathological processes: inflammation, with increased endothelial permeability, endothelial activation, and monocyte recruitment; growth, with smooth muscle cell proliferation, migration, and matrix synthesis; degeneration, with lipid accumulation; necrosis, possibly related to the cytotoxic effect of oxidized lipid; calcification/ossification, which may represent an active rather than a dystrophic process; and thrombosis, with platelet recruitment and fibrin formation. In this review we discuss these processes and the possible pathological effects of Chlamydia infection and the ensuing phlogosis.

AB - Coronary heart disease is the single most common cause of illness and death in the developed world. Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and plaque disruption with superimposed thrombosis is the main cause of the acute coronary syndromes of unstable angina, myocardial infarction, and sudden death. Atherosclerosis is the result of a complex interaction between blood elements, disturbed flow, and vessel wall abnormality, involving several pathological processes: inflammation, with increased endothelial permeability, endothelial activation, and monocyte recruitment; growth, with smooth muscle cell proliferation, migration, and matrix synthesis; degeneration, with lipid accumulation; necrosis, possibly related to the cytotoxic effect of oxidized lipid; calcification/ossification, which may represent an active rather than a dystrophic process; and thrombosis, with platelet recruitment and fibrin formation. In this review we discuss these processes and the possible pathological effects of Chlamydia infection and the ensuing phlogosis.

KW - ATHEROSCLEROSIS, INFECTION

UR - http://hdl.handle.net/10447/79640

M3 - Article

VL - 1

SP - 31

EP - 40

JO - World Journal of Cardiology

JF - World Journal of Cardiology

SN - 1949-8462

ER -