Atherogenic lipoprotein phenotype and low-density lipoproteins size and subclasses in women with polycystic ovary syndrome

Manfredi Rizzo, Enrico Carmina, Veronica Lazzaroni, Kaspar Berneis, Franca Fruzzetti

Risultato della ricerca: Articlepeer review

95 Citazioni (Scopus)


Context: An altered lipid profile is common in polycystic ovary syndrome(PCOS) and is usually characterized by increased triglyceridesand low high-density lipoprotein (HDL)-cholesterol levels. In the generalpopulation, these alterations are often associated with the increaseof small low-density lipoproteins (LDLs) in the so-called“atherogenic lipoprotein phenotype” (ALP) that determines a furtherincrease of cardiovascular risk. In this study, we evaluated the presenceof ALP in the plasma of women with PCOS.Setting: Measurements and analysis of LDL size were performed atthe Clinic of Endocrinology, Diabetes, and Clinical Nutrition, UniversityHospital, Zurich. PCOS patients were recruited at the Departmentof Clinical Medicine, University of Palermo, and the Departmentof Obstetrics and Gynecology, University of Pisa.Patients: Thirty patients with PCOS (hyperandrogenism andchronic anovulation) and 24 matched controls were studied. Anthropometricdata, blood glucose, serum insulin lipid profile, and LDL sizeand subclasses were evaluated.Results: Compared with controls, patients with PCOS had higherplasma concentrations of insulin and triglycerides and lower HDLcholesterolconcentrations but no differences in LDL-cholesterol andtotal cholesterol. Patients with PCOS had smaller LDL size due to areduction in LDL subclass I, with a concomitant increase in LDLsubclasses III and IV. Fourteen PCOS patients had an increase ofsmaller LDL particles, and it represented the second most commonlipid alteration after decrease in HDL-cholesterol. However, becausein this PCOS population hypertriglyceridemia was only present intwo patients, complete ALP was relatively uncommon.Conclusions: Increase of type III or type IV LDL subclasses is acommon finding in PCOS and represents the second most commonlipid alteration after HDL-cholesterol decrease. However, in ourPCOS patients, because of relatively low triglyceride levels, completeALP is uncommon
Lingua originaleEnglish
pagine (da-a)186-189
Numero di pagine4
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1303???
  • ???subjectarea.asjc.1300.1310???
  • ???subjectarea.asjc.1300.1308???
  • ???subjectarea.asjc.2700.2704???


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