Association study between beta-defensin gene polymorphisms and mastitis resistance in Valle del Belice dairy sheep breed

Baldassare Portolano, Salvatore Mastrangelo, Maria Teresa Sardina, Marco Tolone, Giuseppina Monteleone, Rosalia Di Gerlando, Anna Maria Sutera, Baldassare Portolano, Giuseppina Monteleone, Marco Tolone, Salvatore Mastrangelo, Rosalia Di Gerlando, Anna M. Sutera

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

Mastitis is generally caused by bacteria, and it is the most common disease in livestock species. Defensins are peptides with a broad spectrum of antimicrobial activity and β-defensin genes have been studied in several livestock species due to their important role in the innate immune response. The aim of this study was to establish an association between polymorphisms in the β-defensin 1 and 2 genes and mastitis resistance in the Valle del Belice dairy sheep. Data consisted of 1,855 and 2,804 observations for case and control group, respectively. Six single nucleotide polymorphisms and seven haplotypes were selected for association studies with mastitis. In particular, polymorphism G1747A on β-defensin 1 gene was associated with susceptibility to mastitis, while polymorphism G1659A on β-defensin 2 gene was associated with resistance to mastitis. Haplotypes ACAGGG and GCAGGG were associated with resistance to mastitis, whereas haplotype ACGGGG was associated with susceptibility to mastitis. The present study has firstly suggested the possible associations of β-defensin gene polymorphisms with mastitis resistance traits and showed the presence of interesting haplotypes in Valle del Belice dairy sheep breed. Results from association analysis provided preliminary evidence that β-defensins could be used as candidate genes or molecular markers for the improvement of ovine mastitis resistance traits in Valle del Belice dairy breed.
Lingua originaleEnglish
pagine (da-a)18-21
Numero di pagine4
RivistaSmall Ruminant Research
Stato di pubblicazionePublished - 2016

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beta-Defensins
dairy breeds
dairy sheep
Mastitis
sheep breeds
mastitis
Sheep
genetic polymorphism
Genes
Haplotypes
genes
haplotypes
Defensins
Livestock
livestock
anti-infective agents
peptides
Bacteria
sheep
Control Groups

All Science Journal Classification (ASJC) codes

  • Food Animals
  • Animal Science and Zoology

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title = "Association study between beta-defensin gene polymorphisms and mastitis resistance in Valle del Belice dairy sheep breed",
abstract = "Mastitis is generally caused by bacteria, and it is the most common disease in livestock species. Defensins are peptides with a broad spectrum of antimicrobial activity and β-defensin genes have been studied in several livestock species due to their important role in the innate immune response. The aim of this study was to establish an association between polymorphisms in the β-defensin 1 and 2 genes and mastitis resistance in the Valle del Belice dairy sheep. Data consisted of 1,855 and 2,804 observations for case and control group, respectively. Six single nucleotide polymorphisms and seven haplotypes were selected for association studies with mastitis. In particular, polymorphism G1747A on β-defensin 1 gene was associated with susceptibility to mastitis, while polymorphism G1659A on β-defensin 2 gene was associated with resistance to mastitis. Haplotypes ACAGGG and GCAGGG were associated with resistance to mastitis, whereas haplotype ACGGGG was associated with susceptibility to mastitis. The present study has firstly suggested the possible associations of β-defensin gene polymorphisms with mastitis resistance traits and showed the presence of interesting haplotypes in Valle del Belice dairy sheep breed. Results from association analysis provided preliminary evidence that β-defensins could be used as candidate genes or molecular markers for the improvement of ovine mastitis resistance traits in Valle del Belice dairy breed.",
author = "Baldassare Portolano and Salvatore Mastrangelo and Sardina, {Maria Teresa} and Marco Tolone and Giuseppina Monteleone and {Di Gerlando}, Rosalia and Sutera, {Anna Maria} and Baldassare Portolano and Giuseppina Monteleone and Marco Tolone and Salvatore Mastrangelo and {Di Gerlando}, Rosalia and Sutera, {Anna M.}",
year = "2016",
language = "English",
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journal = "Small Ruminant Research",
issn = "0921-4488",
publisher = "Elsevier",

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TY - JOUR

T1 - Association study between beta-defensin gene polymorphisms and mastitis resistance in Valle del Belice dairy sheep breed

AU - Portolano, Baldassare

AU - Mastrangelo, Salvatore

AU - Sardina, Maria Teresa

AU - Tolone, Marco

AU - Monteleone, Giuseppina

AU - Di Gerlando, Rosalia

AU - Sutera, Anna Maria

AU - Portolano, Baldassare

AU - Monteleone, Giuseppina

AU - Tolone, Marco

AU - Mastrangelo, Salvatore

AU - Di Gerlando, Rosalia

AU - Sutera, Anna M.

PY - 2016

Y1 - 2016

N2 - Mastitis is generally caused by bacteria, and it is the most common disease in livestock species. Defensins are peptides with a broad spectrum of antimicrobial activity and β-defensin genes have been studied in several livestock species due to their important role in the innate immune response. The aim of this study was to establish an association between polymorphisms in the β-defensin 1 and 2 genes and mastitis resistance in the Valle del Belice dairy sheep. Data consisted of 1,855 and 2,804 observations for case and control group, respectively. Six single nucleotide polymorphisms and seven haplotypes were selected for association studies with mastitis. In particular, polymorphism G1747A on β-defensin 1 gene was associated with susceptibility to mastitis, while polymorphism G1659A on β-defensin 2 gene was associated with resistance to mastitis. Haplotypes ACAGGG and GCAGGG were associated with resistance to mastitis, whereas haplotype ACGGGG was associated with susceptibility to mastitis. The present study has firstly suggested the possible associations of β-defensin gene polymorphisms with mastitis resistance traits and showed the presence of interesting haplotypes in Valle del Belice dairy sheep breed. Results from association analysis provided preliminary evidence that β-defensins could be used as candidate genes or molecular markers for the improvement of ovine mastitis resistance traits in Valle del Belice dairy breed.

AB - Mastitis is generally caused by bacteria, and it is the most common disease in livestock species. Defensins are peptides with a broad spectrum of antimicrobial activity and β-defensin genes have been studied in several livestock species due to their important role in the innate immune response. The aim of this study was to establish an association between polymorphisms in the β-defensin 1 and 2 genes and mastitis resistance in the Valle del Belice dairy sheep. Data consisted of 1,855 and 2,804 observations for case and control group, respectively. Six single nucleotide polymorphisms and seven haplotypes were selected for association studies with mastitis. In particular, polymorphism G1747A on β-defensin 1 gene was associated with susceptibility to mastitis, while polymorphism G1659A on β-defensin 2 gene was associated with resistance to mastitis. Haplotypes ACAGGG and GCAGGG were associated with resistance to mastitis, whereas haplotype ACGGGG was associated with susceptibility to mastitis. The present study has firstly suggested the possible associations of β-defensin gene polymorphisms with mastitis resistance traits and showed the presence of interesting haplotypes in Valle del Belice dairy sheep breed. Results from association analysis provided preliminary evidence that β-defensins could be used as candidate genes or molecular markers for the improvement of ovine mastitis resistance traits in Valle del Belice dairy breed.

UR - http://hdl.handle.net/10447/162421

M3 - Article

SP - 18

EP - 21

JO - Small Ruminant Research

JF - Small Ruminant Research

SN - 0921-4488

ER -