Association of obesity and diabetes with thyroid nodules

Carla Giordano, Sonya Vasto, Silvio Buscemi, Maria Fatima Massenti, Carla Giordano, Anna Maria Barile, Giuseppe Rosafio, Nadia Rini, Carola Buscemi, Davide Corleo, Fabio Galvano, Silvio Buscemi, Davide Corleo, Fabio Galvano

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Aim: There are conflicting data concerning the possibility that obesity and diabetes raise the risk of thyroid nodules. The incidence of thyroid nodules is increasing, as is that of obesity and diabetes; therefore, understanding whether these metabolic and nutritional disorders influence nodular thyroid disease is important for organizing prevention strategies. This study investigated the association between thyroid nodules, obesity, diabetes, and dietary habits. Materials and methods: A cohort of randomly selected adults (455 males, 746 females; age: 18â90 years) living in Palermo (Italy), a mild iodine deficiency area, was cross-sectionally investigated. Participants underwent high-resolution ultrasonographic evaluation of the thyroid, and answered a food frequency questionnaire. Laboratory blood measurements were obtained in 587 participants. Results and discussion: Thyroid nodules were detected in 475 (39.5%) participants. The number of thyroid nodules was correlated with age (r = 0.19; P < 0.001), gender (r = 0.08; P = 0.005), and body mass index (r = 0.07; P = 0.02). No significant correlation was observed between the number of nodules and glycated hemoglobin, serum insulin concentrations, and homeostasis model assessment of insulin resistance. Age-adjusted and gender-adjusted prevalence of both overweight/obesity and type 2 diabetes of each group of participants divided according to the number of nodules significantly increased with the number of nodules (P < 0.05 in both cases). The group of participants with nodules exhibited a significantly lower age-adjusted and gender-adjusted habitual intake of milk (P = 0.02). Multivariate regression analysis showed that age, gender, body mass index, diabetes, and habitual consumption of milk were independently correlated with presence of thyroid nodules. Conclusion: This study seems to indicate that an association exists between obesity, diabetes, and thyroid nodules.
Lingua originaleEnglish
pagine (da-a)339-347
Numero di pagine9
RivistaDefault journal
Volume60
Stato di pubblicazionePublished - 2017

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Thyroid Nodule
Obesity
Milk
Body Mass Index
Nutrition Disorders
Thyroid Diseases
Glycosylated Hemoglobin A
Feeding Behavior
Iodine
Type 2 Diabetes Mellitus
Italy
Insulin Resistance
Thyroid Gland
Homeostasis
Multivariate Analysis
Regression Analysis
Insulin
Food
Incidence
Serum

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cita questo

Association of obesity and diabetes with thyroid nodules. / Giordano, Carla; Vasto, Sonya; Buscemi, Silvio; Massenti, Maria Fatima; Giordano, Carla; Barile, Anna Maria; Rosafio, Giuseppe; Rini, Nadia; Buscemi, Carola; Corleo, Davide; Galvano, Fabio; Buscemi, Silvio; Corleo, Davide; Galvano, Fabio.

In: Default journal, Vol. 60, 2017, pag. 339-347.

Risultato della ricerca: Article

Giordano, C, Vasto, S, Buscemi, S, Massenti, MF, Giordano, C, Barile, AM, Rosafio, G, Rini, N, Buscemi, C, Corleo, D, Galvano, F, Buscemi, S, Corleo, D & Galvano, F 2017, 'Association of obesity and diabetes with thyroid nodules', Default journal, vol. 60, pagg. 339-347.
Giordano, Carla ; Vasto, Sonya ; Buscemi, Silvio ; Massenti, Maria Fatima ; Giordano, Carla ; Barile, Anna Maria ; Rosafio, Giuseppe ; Rini, Nadia ; Buscemi, Carola ; Corleo, Davide ; Galvano, Fabio ; Buscemi, Silvio ; Corleo, Davide ; Galvano, Fabio. / Association of obesity and diabetes with thyroid nodules. In: Default journal. 2017 ; Vol. 60. pagg. 339-347.
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title = "Association of obesity and diabetes with thyroid nodules",
abstract = "Aim: There are conflicting data concerning the possibility that obesity and diabetes raise the risk of thyroid nodules. The incidence of thyroid nodules is increasing, as is that of obesity and diabetes; therefore, understanding whether these metabolic and nutritional disorders influence nodular thyroid disease is important for organizing prevention strategies. This study investigated the association between thyroid nodules, obesity, diabetes, and dietary habits. Materials and methods: A cohort of randomly selected adults (455 males, 746 females; age: 18{\^a}90 years) living in Palermo (Italy), a mild iodine deficiency area, was cross-sectionally investigated. Participants underwent high-resolution ultrasonographic evaluation of the thyroid, and answered a food frequency questionnaire. Laboratory blood measurements were obtained in 587 participants. Results and discussion: Thyroid nodules were detected in 475 (39.5{\%}) participants. The number of thyroid nodules was correlated with age (r = 0.19; P < 0.001), gender (r = 0.08; P = 0.005), and body mass index (r = 0.07; P = 0.02). No significant correlation was observed between the number of nodules and glycated hemoglobin, serum insulin concentrations, and homeostasis model assessment of insulin resistance. Age-adjusted and gender-adjusted prevalence of both overweight/obesity and type 2 diabetes of each group of participants divided according to the number of nodules significantly increased with the number of nodules (P < 0.05 in both cases). The group of participants with nodules exhibited a significantly lower age-adjusted and gender-adjusted habitual intake of milk (P = 0.02). Multivariate regression analysis showed that age, gender, body mass index, diabetes, and habitual consumption of milk were independently correlated with presence of thyroid nodules. Conclusion: This study seems to indicate that an association exists between obesity, diabetes, and thyroid nodules.",
keywords = "Diabetes and Metabolism; Endocrinology, Diabetes; Diet; Milk; Obesity; Thyroid nodules; Endocrinology",
author = "Carla Giordano and Sonya Vasto and Silvio Buscemi and Massenti, {Maria Fatima} and Carla Giordano and Barile, {Anna Maria} and Giuseppe Rosafio and Nadia Rini and Carola Buscemi and Davide Corleo and Fabio Galvano and Silvio Buscemi and Davide Corleo and Fabio Galvano",
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TY - JOUR

T1 - Association of obesity and diabetes with thyroid nodules

AU - Giordano, Carla

AU - Vasto, Sonya

AU - Buscemi, Silvio

AU - Massenti, Maria Fatima

AU - Giordano, Carla

AU - Barile, Anna Maria

AU - Rosafio, Giuseppe

AU - Rini, Nadia

AU - Buscemi, Carola

AU - Corleo, Davide

AU - Galvano, Fabio

AU - Buscemi, Silvio

AU - Corleo, Davide

AU - Galvano, Fabio

PY - 2017

Y1 - 2017

N2 - Aim: There are conflicting data concerning the possibility that obesity and diabetes raise the risk of thyroid nodules. The incidence of thyroid nodules is increasing, as is that of obesity and diabetes; therefore, understanding whether these metabolic and nutritional disorders influence nodular thyroid disease is important for organizing prevention strategies. This study investigated the association between thyroid nodules, obesity, diabetes, and dietary habits. Materials and methods: A cohort of randomly selected adults (455 males, 746 females; age: 18â90 years) living in Palermo (Italy), a mild iodine deficiency area, was cross-sectionally investigated. Participants underwent high-resolution ultrasonographic evaluation of the thyroid, and answered a food frequency questionnaire. Laboratory blood measurements were obtained in 587 participants. Results and discussion: Thyroid nodules were detected in 475 (39.5%) participants. The number of thyroid nodules was correlated with age (r = 0.19; P < 0.001), gender (r = 0.08; P = 0.005), and body mass index (r = 0.07; P = 0.02). No significant correlation was observed between the number of nodules and glycated hemoglobin, serum insulin concentrations, and homeostasis model assessment of insulin resistance. Age-adjusted and gender-adjusted prevalence of both overweight/obesity and type 2 diabetes of each group of participants divided according to the number of nodules significantly increased with the number of nodules (P < 0.05 in both cases). The group of participants with nodules exhibited a significantly lower age-adjusted and gender-adjusted habitual intake of milk (P = 0.02). Multivariate regression analysis showed that age, gender, body mass index, diabetes, and habitual consumption of milk were independently correlated with presence of thyroid nodules. Conclusion: This study seems to indicate that an association exists between obesity, diabetes, and thyroid nodules.

AB - Aim: There are conflicting data concerning the possibility that obesity and diabetes raise the risk of thyroid nodules. The incidence of thyroid nodules is increasing, as is that of obesity and diabetes; therefore, understanding whether these metabolic and nutritional disorders influence nodular thyroid disease is important for organizing prevention strategies. This study investigated the association between thyroid nodules, obesity, diabetes, and dietary habits. Materials and methods: A cohort of randomly selected adults (455 males, 746 females; age: 18â90 years) living in Palermo (Italy), a mild iodine deficiency area, was cross-sectionally investigated. Participants underwent high-resolution ultrasonographic evaluation of the thyroid, and answered a food frequency questionnaire. Laboratory blood measurements were obtained in 587 participants. Results and discussion: Thyroid nodules were detected in 475 (39.5%) participants. The number of thyroid nodules was correlated with age (r = 0.19; P < 0.001), gender (r = 0.08; P = 0.005), and body mass index (r = 0.07; P = 0.02). No significant correlation was observed between the number of nodules and glycated hemoglobin, serum insulin concentrations, and homeostasis model assessment of insulin resistance. Age-adjusted and gender-adjusted prevalence of both overweight/obesity and type 2 diabetes of each group of participants divided according to the number of nodules significantly increased with the number of nodules (P < 0.05 in both cases). The group of participants with nodules exhibited a significantly lower age-adjusted and gender-adjusted habitual intake of milk (P = 0.02). Multivariate regression analysis showed that age, gender, body mass index, diabetes, and habitual consumption of milk were independently correlated with presence of thyroid nodules. Conclusion: This study seems to indicate that an association exists between obesity, diabetes, and thyroid nodules.

KW - Diabetes and Metabolism; Endocrinology

KW - Diabetes; Diet; Milk; Obesity; Thyroid nodules; Endocrinology

UR - http://hdl.handle.net/10447/273048

M3 - Article

VL - 60

SP - 339

EP - 347

JO - Default journal

JF - Default journal

ER -