Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status.

Patrizia Proia, Alberto Mendez-Villanueva, Myosotis Massidda, Paweł Cieszczyk, Valentina Ginevičienė, Marco Scorcu, Svitlana B. Drozdovska, Aleksander Stula, Victor Dosenko, Victor Dosenko, Victor Dosenko, Carla Maria Calò, Marek Sawczuk

Risultato della ricerca: Article

1 Citazioni (Scopus)

Abstract

The aim of this study was to investigate the association between the MCT1 (monocarboxylate transporter 1) A1470Tpolymorphism and positional roles in a large cohort of professional football players from five different countries. We compared genotype distributions of the MCT1 A1470T polymorphism between football players (n = 694) and non-athletecontrols (n = 781) from Italy, Poland, Lithuania, Ukraine andMalta, and we analyzed the MCT1 genotype distributions withrespect to the players’ positions in the field (e. g. forwards,midfielders, defenders and goalkeepers). Genomic DNA wasextracted from either buccal epithelium or peripheral bloodusing a standard protocol. In the pooled cohort of Italian, Polish, Lithuanian and Ukrainian football players, forwards(n = 148) were more likely than controls (n = 781) to possessthe A allele (χ2 = 7.067, p = 0.029, FDR q value 0.116), with agreater likelihood of having the AA genotype compared withthe TT genotype (OR= 1.97; C.I. = 1.07-3.64; p = 0.021, FDR qvalue 0.086). The MCT1 AA genotype was significantly morefrequent in forwards then in controls. Further studies are needed to confirm these findings in other professional footballplayer cohorts
Lingua originaleEnglish
Numero di pagine7
RivistaInternational Journal of Sports Medicine
Stato di pubblicazionePublished - 2018

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cita questo

Proia, P., Mendez-Villanueva, A., Massidda, M., Cieszczyk, P., Ginevičienė, V., Scorcu, M., Drozdovska, S. B., Stula, A., Dosenko, V., Dosenko, V., Dosenko, V., Calò, C. M., & Sawczuk, M. (2018). Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status. International Journal of Sports Medicine.