Association of Klotho polymorphisms with healthy aging: a systematic review andmeta-analysis.

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18 Citazioni (Scopus)

Abstract

Today it is clearly evident that genetic background constitutes an integral part of aging and longevity. Many studies on long-lived people have been conductedemphasizing the role of certain genes in long life. Classic case-control studies,genome-wide association studies, and high-throughput sequencing have permittedidentification of a variety of genetic variants seemingly associated withlongevity. Over the years, aging research has focused on the insulin/insulin-likegrowth factor-1 (IGF-1) signaling pathway because of its evolutionarily conservedcorrelation with life-span extension in model animals. Indeed, manysingle-nucleotide polymorphisms (SNPs) associated with longevity were identified in genes encoding proteins that take part in this metabolic pathway. Closelyrelated to this pathway is the Klotho gene. It encodes a type-I membrane protein expressed in two forms, membrane and secreted. The latter form suppressesoxidative stress and growth factor signaling and regulates ion channels andtransporters. In particular, its over-expression seems to be able to suppressinsulin/IGF-1 signaling extending life span. Thus, our aim was to assemble theresults in the literature concerning the association between the functionalvariant of the Klotho "KL-VS" stretch, which contains six polymorphisms inlinkage disequilibrium, and successful aging to quantify the possible effect ofthe variants. The results of our systematic review indicate that the Klotho KL-VSvariant is associated with healthy aging.
Lingua originaleEnglish
pagine (da-a)212-216
Numero di pagine5
RivistaRejuvenation Research
Volume17
Stato di pubblicazionePublished - 2014

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Insulin
Genome-Wide Association Study
Life Expectancy
Metabolic Networks and Pathways
Ion Channels
Genes
Single Nucleotide Polymorphism
Case-Control Studies
Intercellular Signaling Peptides and Proteins
Membrane Proteins
Nucleotides
Animal Models
Membranes
Research
Proteins
Genetic Background

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

Cita questo

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title = "Association of Klotho polymorphisms with healthy aging: a systematic review andmeta-analysis.",
abstract = "Today it is clearly evident that genetic background constitutes an integral part of aging and longevity. Many studies on long-lived people have been conductedemphasizing the role of certain genes in long life. Classic case-control studies,genome-wide association studies, and high-throughput sequencing have permittedidentification of a variety of genetic variants seemingly associated withlongevity. Over the years, aging research has focused on the insulin/insulin-likegrowth factor-1 (IGF-1) signaling pathway because of its evolutionarily conservedcorrelation with life-span extension in model animals. Indeed, manysingle-nucleotide polymorphisms (SNPs) associated with longevity were identified in genes encoding proteins that take part in this metabolic pathway. Closelyrelated to this pathway is the Klotho gene. It encodes a type-I membrane protein expressed in two forms, membrane and secreted. The latter form suppressesoxidative stress and growth factor signaling and regulates ion channels andtransporters. In particular, its over-expression seems to be able to suppressinsulin/IGF-1 signaling extending life span. Thus, our aim was to assemble theresults in the literature concerning the association between the functionalvariant of the Klotho {"}KL-VS{"} stretch, which contains six polymorphisms inlinkage disequilibrium, and successful aging to quantify the possible effect ofthe variants. The results of our systematic review indicate that the Klotho KL-VSvariant is associated with healthy aging.",
author = "Claudia Virruso and Calogero Caruso and Giulia Accardi and Giuseppina Candore",
year = "2014",
language = "English",
volume = "17",
pages = "212--216",
journal = "Rejuvenation Research",
issn = "1549-1684",
publisher = "Mary Ann Liebert Inc.",

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TY - JOUR

T1 - Association of Klotho polymorphisms with healthy aging: a systematic review andmeta-analysis.

AU - Virruso, Claudia

AU - Caruso, Calogero

AU - Accardi, Giulia

AU - Candore, Giuseppina

PY - 2014

Y1 - 2014

N2 - Today it is clearly evident that genetic background constitutes an integral part of aging and longevity. Many studies on long-lived people have been conductedemphasizing the role of certain genes in long life. Classic case-control studies,genome-wide association studies, and high-throughput sequencing have permittedidentification of a variety of genetic variants seemingly associated withlongevity. Over the years, aging research has focused on the insulin/insulin-likegrowth factor-1 (IGF-1) signaling pathway because of its evolutionarily conservedcorrelation with life-span extension in model animals. Indeed, manysingle-nucleotide polymorphisms (SNPs) associated with longevity were identified in genes encoding proteins that take part in this metabolic pathway. Closelyrelated to this pathway is the Klotho gene. It encodes a type-I membrane protein expressed in two forms, membrane and secreted. The latter form suppressesoxidative stress and growth factor signaling and regulates ion channels andtransporters. In particular, its over-expression seems to be able to suppressinsulin/IGF-1 signaling extending life span. Thus, our aim was to assemble theresults in the literature concerning the association between the functionalvariant of the Klotho "KL-VS" stretch, which contains six polymorphisms inlinkage disequilibrium, and successful aging to quantify the possible effect ofthe variants. The results of our systematic review indicate that the Klotho KL-VSvariant is associated with healthy aging.

AB - Today it is clearly evident that genetic background constitutes an integral part of aging and longevity. Many studies on long-lived people have been conductedemphasizing the role of certain genes in long life. Classic case-control studies,genome-wide association studies, and high-throughput sequencing have permittedidentification of a variety of genetic variants seemingly associated withlongevity. Over the years, aging research has focused on the insulin/insulin-likegrowth factor-1 (IGF-1) signaling pathway because of its evolutionarily conservedcorrelation with life-span extension in model animals. Indeed, manysingle-nucleotide polymorphisms (SNPs) associated with longevity were identified in genes encoding proteins that take part in this metabolic pathway. Closelyrelated to this pathway is the Klotho gene. It encodes a type-I membrane protein expressed in two forms, membrane and secreted. The latter form suppressesoxidative stress and growth factor signaling and regulates ion channels andtransporters. In particular, its over-expression seems to be able to suppressinsulin/IGF-1 signaling extending life span. Thus, our aim was to assemble theresults in the literature concerning the association between the functionalvariant of the Klotho "KL-VS" stretch, which contains six polymorphisms inlinkage disequilibrium, and successful aging to quantify the possible effect ofthe variants. The results of our systematic review indicate that the Klotho KL-VSvariant is associated with healthy aging.

UR - http://hdl.handle.net/10447/100471

M3 - Article

VL - 17

SP - 212

EP - 216

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

ER -