Association between uric acid and renal function in hypertensive patients: Which role for systemic vascular involvement?

Giuseppe Mule', Calogero Geraci, Santina Cottone, Giulio Geraci, Antonella Castiglia, Claudia Cusumano, Francesca Gervasi, Francesco D'Ignoto, Manuela Mogavero, Massimiliano Morreale

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

The role of systemic vascular involvement in mediating the association between serum uric acid (SUA) and renal function in hypertension has not been explored. Main purpose of our study was to investigate whether morphofunctional vascular changes, assessed as carotid intima-media thickness (cIMT) and aortic pulse wave velocity (aPWV), might mediate the association between SUA and renal damage. We enrolled 523 hypertensive subjects with or without chronic kidney disease and divided population into tertiles of SUA based on sex-specific cutoff values. cIMT and aPWV were higher in uppermost SUA-tertile patients when compared to those in the lowest ones (all P < .001). Uricemia strongly correlated with cIMT and aPWV at univariate analysis (P < .001) and with cIMT after adjustment for confounders (P < .001). Adjustment for cIMT attenuated the relationship between SUA and estimated glomerular filtration rate (P = .019). Systemic vascular changes seem partially to mediate the association between SUA and renal function in hypertensive patients, regardless of kidney function.
Lingua originaleEnglish
pagine (da-a)559-569
Numero di pagine11
RivistaDefault journal
Stato di pubblicazionePublished - 2016

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Carotid Intima-Media Thickness
Uric Acid
Blood Vessels
Kidney
Pulse Wave Analysis
Serum
Glomerular Filtration Rate
Chronic Renal Insufficiency
Hypertension
Population

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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Association between uric acid and renal function in hypertensive patients: Which role for systemic vascular involvement? / Mule', Giuseppe; Geraci, Calogero; Cottone, Santina; Geraci, Giulio; Castiglia, Antonella; Cusumano, Claudia; Gervasi, Francesca; D'Ignoto, Francesco; Mogavero, Manuela; Morreale, Massimiliano.

In: Default journal, 2016, pag. 559-569.

Risultato della ricerca: Article

Mule', G, Geraci, C, Cottone, S, Geraci, G, Castiglia, A, Cusumano, C, Gervasi, F, D'Ignoto, F, Mogavero, M & Morreale, M 2016, 'Association between uric acid and renal function in hypertensive patients: Which role for systemic vascular involvement?', Default journal, pagg. 559-569.
Mule' G, Geraci C, Cottone S, Geraci G, Castiglia A, Cusumano C e altri. Association between uric acid and renal function in hypertensive patients: Which role for systemic vascular involvement? Default journal. 2016;559-569.
Mule', Giuseppe ; Geraci, Calogero ; Cottone, Santina ; Geraci, Giulio ; Castiglia, Antonella ; Cusumano, Claudia ; Gervasi, Francesca ; D'Ignoto, Francesco ; Mogavero, Manuela ; Morreale, Massimiliano. / Association between uric acid and renal function in hypertensive patients: Which role for systemic vascular involvement?. In: Default journal. 2016 ; pagg. 559-569.
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AU - Mule', Giuseppe

AU - Geraci, Calogero

AU - Cottone, Santina

AU - Geraci, Giulio

AU - Castiglia, Antonella

AU - Cusumano, Claudia

AU - Gervasi, Francesca

AU - D'Ignoto, Francesco

AU - Mogavero, Manuela

AU - Morreale, Massimiliano

PY - 2016

Y1 - 2016

N2 - The role of systemic vascular involvement in mediating the association between serum uric acid (SUA) and renal function in hypertension has not been explored. Main purpose of our study was to investigate whether morphofunctional vascular changes, assessed as carotid intima-media thickness (cIMT) and aortic pulse wave velocity (aPWV), might mediate the association between SUA and renal damage. We enrolled 523 hypertensive subjects with or without chronic kidney disease and divided population into tertiles of SUA based on sex-specific cutoff values. cIMT and aPWV were higher in uppermost SUA-tertile patients when compared to those in the lowest ones (all P < .001). Uricemia strongly correlated with cIMT and aPWV at univariate analysis (P < .001) and with cIMT after adjustment for confounders (P < .001). Adjustment for cIMT attenuated the relationship between SUA and estimated glomerular filtration rate (P = .019). Systemic vascular changes seem partially to mediate the association between SUA and renal function in hypertensive patients, regardless of kidney function.

AB - The role of systemic vascular involvement in mediating the association between serum uric acid (SUA) and renal function in hypertension has not been explored. Main purpose of our study was to investigate whether morphofunctional vascular changes, assessed as carotid intima-media thickness (cIMT) and aortic pulse wave velocity (aPWV), might mediate the association between SUA and renal damage. We enrolled 523 hypertensive subjects with or without chronic kidney disease and divided population into tertiles of SUA based on sex-specific cutoff values. cIMT and aPWV were higher in uppermost SUA-tertile patients when compared to those in the lowest ones (all P < .001). Uricemia strongly correlated with cIMT and aPWV at univariate analysis (P < .001) and with cIMT after adjustment for confounders (P < .001). Adjustment for cIMT attenuated the relationship between SUA and estimated glomerular filtration rate (P = .019). Systemic vascular changes seem partially to mediate the association between SUA and renal function in hypertensive patients, regardless of kidney function.

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JO - Default journal

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