Abstract
Lingua originale | English |
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pagine (da-a) | 559-569 |
Numero di pagine | 11 |
Rivista | Default journal |
Stato di pubblicazione | Published - 2016 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Cardiology and Cardiovascular Medicine
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Association between uric acid and renal function in hypertensive patients: Which role for systemic vascular involvement? / Mule', Giuseppe; Geraci, Calogero; Cottone, Santina; Geraci, Giulio; Castiglia, Antonella; Cusumano, Claudia; Gervasi, Francesca; D'Ignoto, Francesco; Mogavero, Manuela; Morreale, Massimiliano.
In: Default journal, 2016, pag. 559-569.Risultato della ricerca: Article
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TY - JOUR
T1 - Association between uric acid and renal function in hypertensive patients: Which role for systemic vascular involvement?
AU - Mule', Giuseppe
AU - Geraci, Calogero
AU - Cottone, Santina
AU - Geraci, Giulio
AU - Castiglia, Antonella
AU - Cusumano, Claudia
AU - Gervasi, Francesca
AU - D'Ignoto, Francesco
AU - Mogavero, Manuela
AU - Morreale, Massimiliano
PY - 2016
Y1 - 2016
N2 - The role of systemic vascular involvement in mediating the association between serum uric acid (SUA) and renal function in hypertension has not been explored. Main purpose of our study was to investigate whether morphofunctional vascular changes, assessed as carotid intima-media thickness (cIMT) and aortic pulse wave velocity (aPWV), might mediate the association between SUA and renal damage. We enrolled 523 hypertensive subjects with or without chronic kidney disease and divided population into tertiles of SUA based on sex-specific cutoff values. cIMT and aPWV were higher in uppermost SUA-tertile patients when compared to those in the lowest ones (all P < .001). Uricemia strongly correlated with cIMT and aPWV at univariate analysis (P < .001) and with cIMT after adjustment for confounders (P < .001). Adjustment for cIMT attenuated the relationship between SUA and estimated glomerular filtration rate (P = .019). Systemic vascular changes seem partially to mediate the association between SUA and renal function in hypertensive patients, regardless of kidney function.
AB - The role of systemic vascular involvement in mediating the association between serum uric acid (SUA) and renal function in hypertension has not been explored. Main purpose of our study was to investigate whether morphofunctional vascular changes, assessed as carotid intima-media thickness (cIMT) and aortic pulse wave velocity (aPWV), might mediate the association between SUA and renal damage. We enrolled 523 hypertensive subjects with or without chronic kidney disease and divided population into tertiles of SUA based on sex-specific cutoff values. cIMT and aPWV were higher in uppermost SUA-tertile patients when compared to those in the lowest ones (all P < .001). Uricemia strongly correlated with cIMT and aPWV at univariate analysis (P < .001) and with cIMT after adjustment for confounders (P < .001). Adjustment for cIMT attenuated the relationship between SUA and estimated glomerular filtration rate (P = .019). Systemic vascular changes seem partially to mediate the association between SUA and renal function in hypertensive patients, regardless of kidney function.
UR - http://hdl.handle.net/10447/179512
UR - http://www.elsevier.com
M3 - Article
SP - 559
EP - 569
JO - Default journal
JF - Default journal
ER -