Association between the ACE I/D polymorphism and physical activity in Polish women

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Angiotensin converting enzyme gene (ACE) is the mostfrequently investigated genetic marker in the context of geneticconditioning of athletic predispositions. However, the knowledgeof ACE’s potential modifying effect on changes in selected bodytraits achieved through a training programme is still limited.Therefore, we have decided to check whether selected bodymass, body composition variables, oxygen uptake parameters aswell as strength/speed parameters observed in physically activeparticipants will be modulated by the ACE I/D polymorphism.The genotype distribution was examined in a group of 201young healthy women measured for chosen traits before andafter the completion of a 12-week moderate-intensive aerobictraining programme. Our results revealed the significantgenotype × training interactions for VEmax and power ofcountermovement jump, whereas training improvementswere demonstrated for almost all parameters. In addition,main effects of the ACE I/D genotype on TGL, HDL, glucoseand 10 m run were observed. A significant increase in VEmaxwas demonstrated for II and DD genotypes, but not for IDheterozygotes. The greatest gain in power of countermovementjump was observed in II homozygotes, although DD and IDwere associated with a significant increase as well. Our studyindicated that the polymorphism was associated with changesin VEmax and power of countermovement jump in response toa 12-week aerobic training programme in Caucasian women.However, more experimental studies are needed to establish theACE gene × physical activity interactions
Lingua originaleEnglish
Numero di pagine7
Stato di pubblicazionePublished - 2016


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