TY - JOUR
T1 - Association between sarcopenia and diabetes: a systematic review and meta-analysis of observational studies
AU - Veronese, Nicola
AU - Petrovic, Mirko
AU - Pizzol, Damiano
AU - Soysal, Pinar
AU - Veronese, Nicola
AU - Smith, Lee
AU - Sieber, Cornel
AU - Strandberg, Timo
AU - Demurtas, Jacopo
AU - Strandberg, Timo
AU - Maggi, Stefania
AU - Sinclair, Alan
AU - Bourdel-Marchasson, Isabelle
PY - 2019
Y1 - 2019
N2 - Purpose: Sarcopenia and diabetes are two common conditions in older people. Some recent literature has proposed that these two conditions can be associated. However, to date, no attempt has been made to collate this literature. Therefore, we aimed to summarize the prevalence of sarcopenia in diabetes (and vice versa) and the prevalence of sarcopenia in people with diabetes complications, through a systematic review and meta-analysis. Methods: Two authors searched major electronic databases from inception until March 2019 for case control/cross-sectional/longitudinal studies investigating sarcopenia and diabetes. The strength of the reciprocal associations between sarcopenia and diabetes was assessed through odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounders, where possible. Results: From 953 potential eligible articles, 20 were included in the systematic review, with 17 providing data for meta-analysis. Overall, 54,676 participants were included (mean age = 65.4 years). Diabetic participants had an increased prevalence of sarcopenia compared to controls (n = 10; OR = 1.635; 95% CI 1.204–2.220; p = 0.002; I 2 = 67%), whilst, after adjusting for potential confounders, sarcopenia was associated with an increased odds of having diabetes (OR = 2.067; 95% CI 1.396–3.624; p < 0.0001; I 2 = 0%). In 1868 diabetic participants with a complication, there was an increased prevalence of sarcopenia (OR = 2.446; 95% CI 1.839–3.254; p < 0.0001; I 2 = 0%), as compared with those with no complication. Very limited data existed regarding studies with a longitudinal design. Conclusions: Our study suggests a bidirectional association between diabetes and sarcopenia, particularly when diabetic complications are present. © 2019, © 2019, European Geriatric Medicine Society.
AB - Purpose: Sarcopenia and diabetes are two common conditions in older people. Some recent literature has proposed that these two conditions can be associated. However, to date, no attempt has been made to collate this literature. Therefore, we aimed to summarize the prevalence of sarcopenia in diabetes (and vice versa) and the prevalence of sarcopenia in people with diabetes complications, through a systematic review and meta-analysis. Methods: Two authors searched major electronic databases from inception until March 2019 for case control/cross-sectional/longitudinal studies investigating sarcopenia and diabetes. The strength of the reciprocal associations between sarcopenia and diabetes was assessed through odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounders, where possible. Results: From 953 potential eligible articles, 20 were included in the systematic review, with 17 providing data for meta-analysis. Overall, 54,676 participants were included (mean age = 65.4 years). Diabetic participants had an increased prevalence of sarcopenia compared to controls (n = 10; OR = 1.635; 95% CI 1.204–2.220; p = 0.002; I 2 = 67%), whilst, after adjusting for potential confounders, sarcopenia was associated with an increased odds of having diabetes (OR = 2.067; 95% CI 1.396–3.624; p < 0.0001; I 2 = 0%). In 1868 diabetic participants with a complication, there was an increased prevalence of sarcopenia (OR = 2.446; 95% CI 1.839–3.254; p < 0.0001; I 2 = 0%), as compared with those with no complication. Very limited data existed regarding studies with a longitudinal design. Conclusions: Our study suggests a bidirectional association between diabetes and sarcopenia, particularly when diabetic complications are present. © 2019, © 2019, European Geriatric Medicine Society.
UR - http://hdl.handle.net/10447/463284
M3 - Article
VL - 10
SP - 685
EP - 696
JO - European Geriatric Medicine
JF - European Geriatric Medicine
SN - 1878-7649
ER -