Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease

Salvatore Petta; Vito Di Marco; Rosaria Maria Pipitone; Grazia Pennisi; Stefania Grimaudo; Calogero Camma'; Federica Spatola; Marco Enea; Ciro Celsa; Antonio Craxi; Giulio Marchesini; Aurora Giannetti; Maria Rosa Barcellona; Roberta Boemi

Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease

Salvatore Petta, Vito Di Marco, Rosaria Maria Pipitone, Grazia Pennisi, Stefania Grimaudo, Calogero Camma', Federica Spatola, Marco Enea, Ciro Celsa, Antonio Craxi, Giulio Marchesini, Aurora Giannetti, Maria Rosa Barcellona, Roberta Boemi

Risultato della ricerca: Article › peer review

70 Citazioni (Scopus)

Abstract

Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk for liver-related complications, such as decompensation, hepatocellular carcinoma (HCC), and death; the severity of liver fibrosis and metabolic comorbidities are the main risk factors. A single nucleotide polymorphism in patatin-like phospholipase domain-containing-3 (PNPLA3) gene is associated with higher prevalence of liver damage and HCC, but there are no data from prospective studies of outcomes of patients with this polymorphism. We investigated whether the common rs738409 variant in PNPLA3 gene associates with the occurrence of liver-related events and death in a large cohort of patients with NAFLD.

Lingua originale	English
pagine (da-a)	935-944
Numero di pagine	10
Rivista	Clinical Gastroenterology and Hepatology
Volume	18
Stato di pubblicazione	Published - 2020

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Petta, S., Di Marco, V., Pipitone, R. M., Pennisi, G., Grimaudo, S., Camma', C., Spatola, F., Enea, M., Celsa, C., Craxi, A., Marchesini, G., Giannetti, A., Barcellona, M. R., & Boemi, R. (2020). Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease. Clinical Gastroenterology and Hepatology, 18, 935-944.

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title = "Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease",

abstract = "Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk for liver-related complications, such as decompensation, hepatocellular carcinoma (HCC), and death; the severity of liver fibrosis and metabolic comorbidities are the main risk factors. A single nucleotide polymorphism in patatin-like phospholipase domain-containing-3 (PNPLA3) gene is associated with higher prevalence of liver damage and HCC, but there are no data from prospective studies of outcomes of patients with this polymorphism. We investigated whether the common rs738409 variant in PNPLA3 gene associates with the occurrence of liver-related events and death in a large cohort of patients with NAFLD.",

author = "Salvatore Petta and {Di Marco}, Vito and Pipitone, {Rosaria Maria} and Grazia Pennisi and Stefania Grimaudo and Calogero Camma' and Federica Spatola and Marco Enea and Ciro Celsa and Antonio Craxi and Giulio Marchesini and Aurora Giannetti and Barcellona, {Maria Rosa} and Roberta Boemi",

year = "2020",

language = "English",

volume = "18",

pages = "935--944",

journal = "Clinical Gastroenterology and Hepatology",

issn = "1542-3565",

publisher = "W.B. Saunders Ltd",

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TY - JOUR

T1 - Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease

AU - Petta, Salvatore

AU - Di Marco, Vito

AU - Pipitone, Rosaria Maria

AU - Pennisi, Grazia

AU - Grimaudo, Stefania

AU - Camma', Calogero

AU - Spatola, Federica

AU - Enea, Marco

AU - Celsa, Ciro

AU - Craxi, Antonio

AU - Marchesini, Giulio

AU - Giannetti, Aurora

AU - Barcellona, Maria Rosa

AU - Boemi, Roberta

PY - 2020

Y1 - 2020

N2 - Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk for liver-related complications, such as decompensation, hepatocellular carcinoma (HCC), and death; the severity of liver fibrosis and metabolic comorbidities are the main risk factors. A single nucleotide polymorphism in patatin-like phospholipase domain-containing-3 (PNPLA3) gene is associated with higher prevalence of liver damage and HCC, but there are no data from prospective studies of outcomes of patients with this polymorphism. We investigated whether the common rs738409 variant in PNPLA3 gene associates with the occurrence of liver-related events and death in a large cohort of patients with NAFLD.

AB - Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk for liver-related complications, such as decompensation, hepatocellular carcinoma (HCC), and death; the severity of liver fibrosis and metabolic comorbidities are the main risk factors. A single nucleotide polymorphism in patatin-like phospholipase domain-containing-3 (PNPLA3) gene is associated with higher prevalence of liver damage and HCC, but there are no data from prospective studies of outcomes of patients with this polymorphism. We investigated whether the common rs738409 variant in PNPLA3 gene associates with the occurrence of liver-related events and death in a large cohort of patients with NAFLD.

UR - http://hdl.handle.net/10447/387172

M3 - Article

SN - 1542-3565

VL - 18

SP - 935

EP - 944

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

ER -

Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease

Abstract

All Science Journal Classification (ASJC) codes

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