Abstract

Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk for liver-related complications, such as decompensation, hepatocellular carcinoma (HCC), and death; the severity of liver fibrosis and metabolic comorbidities are the main risk factors. A single nucleotide polymorphism in patatin-like phospholipase domain-containing-3 (PNPLA3) gene is associated with higher prevalence of liver damage and HCC, but there are no data from prospective studies of outcomes of patients with this polymorphism. We investigated whether the common rs738409 variant in PNPLA3 gene associates with the occurrence of liver-related events and death in a large cohort of patients with NAFLD.
Lingua originaleEnglish
Numero di pagine12
RivistaClinical Gastroenterology and Hepatology
Stato di pubblicazionePublished - 2019

Fingerprint

Phospholipases
Hepatocellular Carcinoma
Liver
Liver Cirrhosis
Genes
Single Nucleotide Polymorphism
Comorbidity
Prospective Studies
Non-alcoholic Fatty Liver Disease

Cita questo

@article{168dee93338e4eafa4c82dcedc2de287,
title = "Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease",
abstract = "Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk for liver-related complications, such as decompensation, hepatocellular carcinoma (HCC), and death; the severity of liver fibrosis and metabolic comorbidities are the main risk factors. A single nucleotide polymorphism in patatin-like phospholipase domain-containing-3 (PNPLA3) gene is associated with higher prevalence of liver damage and HCC, but there are no data from prospective studies of outcomes of patients with this polymorphism. We investigated whether the common rs738409 variant in PNPLA3 gene associates with the occurrence of liver-related events and death in a large cohort of patients with NAFLD.",
author = "Pipitone, {Rosaria Maria} and Salvatore Petta and Marco Enea and Calogero Camma' and {Di Marco}, Vito and Stefania Grimaudo and Grazia Pennisi and Antonio Craxi and Federica Spatola and Ciro Celsa and Aurora Giannetti and Barcellona, {Maria Rosa} and Roberta Boemi",
year = "2019",
language = "English",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease

AU - Pipitone, Rosaria Maria

AU - Petta, Salvatore

AU - Enea, Marco

AU - Camma', Calogero

AU - Di Marco, Vito

AU - Grimaudo, Stefania

AU - Pennisi, Grazia

AU - Craxi, Antonio

AU - Spatola, Federica

AU - Celsa, Ciro

AU - Giannetti, Aurora

AU - Barcellona, Maria Rosa

AU - Boemi, Roberta

PY - 2019

Y1 - 2019

N2 - Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk for liver-related complications, such as decompensation, hepatocellular carcinoma (HCC), and death; the severity of liver fibrosis and metabolic comorbidities are the main risk factors. A single nucleotide polymorphism in patatin-like phospholipase domain-containing-3 (PNPLA3) gene is associated with higher prevalence of liver damage and HCC, but there are no data from prospective studies of outcomes of patients with this polymorphism. We investigated whether the common rs738409 variant in PNPLA3 gene associates with the occurrence of liver-related events and death in a large cohort of patients with NAFLD.

AB - Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk for liver-related complications, such as decompensation, hepatocellular carcinoma (HCC), and death; the severity of liver fibrosis and metabolic comorbidities are the main risk factors. A single nucleotide polymorphism in patatin-like phospholipase domain-containing-3 (PNPLA3) gene is associated with higher prevalence of liver damage and HCC, but there are no data from prospective studies of outcomes of patients with this polymorphism. We investigated whether the common rs738409 variant in PNPLA3 gene associates with the occurrence of liver-related events and death in a large cohort of patients with NAFLD.

UR - http://hdl.handle.net/10447/387172

M3 - Article

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

ER -