Association between dietary folate intake and serum insulin-like growth factor-1 levels in healthy old women

Nicola Veronese, Enzo Manzato, Francesco Bolzetta, Nicola Veronese, Simona Pizzato, Marina De Rui, Sara Carraro, Linda Berton, Irene De Ronch, Toffanello, Miotto, Coin, Giuseppe Sergi

Risultato della ricerca: Articlepeer review

1 Citazioni (Scopus)


Objective: High serum levels of insulin-like growth factor-1 (IGF-1) seem to coincide with higher rates of some types of cancer and the risk of all-cause mortality in old people. Eating vegetables seems to reduce IGF-1 levels because they are rich in micronutrients such as vitamins. This study investigates the possible association between vitamin intake and IGF-1 levels in a representative group of healthy elderly women with Mediterranean dietary habits. Design: This cross-sectional study included 124 healthy women with a mean age of 71.3±4.2years and a mean body mass index (BMI) of 27.37±3.48kg/m2 attending a mild fitness program twice a week at public gyms in Padova. The main parameters considered were IGF-1 (measured by chemiluminescence) and diet, assessed on the basis of a 3-day record and a questionnaire on the frequency with which they usually ate certain foods. Results: The mean IGF-1 level for the sample as a whole was 136.2 ± 38.9. μg/l, and was significantly lower in women with a higher folate intake (p = 0.04). On simple linear analysis, the vitamins found associated with serum IGF-1 levels were: folates (r: -0.25; p = 0.003); vitamin E (r: -0.21; p = 0.01); vitamin D (r: - 0.17; p = 0.03); and riboflavin (r: -0.16; p = 0.03). After removing the effect of calorie, protein, carbohydrate and fat intake, and other known potential confounders (age, BMI, alcohol intake), only folate intake correlated with IGF-1 levels (r = -0.17; p = 0.04). Conclusion: A folate-rich diet could have the effect of lowering circulating IGF-1 levels in elderly women. © 2013 Elsevier Ltd.
Lingua originaleEnglish
pagine (da-a)267-271
Numero di pagine5
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1310???


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