Assessing chronological aging in Saccharomyces cerevisiae

Mario Giuseppe Mirisola, Min Wei, Jia Hu, Valter D. Longo

Risultato della ricerca: Chapter

26 Citazioni (Scopus)

Abstract

Saccharomyces cerevisiae is one of the most studied model organisms for the identification of genes and mechanisms that affect aging. The chronological lifespan (CLS) assay, which monitors the survival of a non-dividing population, is one of the two methods to study aging in yeast. To eliminate potential artifacts and identify genes and signaling pathways that may also affect aging in higher eukaryotes, it is important to determine CLS by multiple methods. Here, we describe these methods as well as the assays to study macromolecular damage during aging in yeast, with a focus on genomic instability.
Lingua originaleEnglish
Titolo della pubblicazione ospiteAssessing chronological aging in Saccharomyces cerevisiae
Pagine463-472
Numero di pagine10
Stato di pubblicazionePublished - 2013

Serie di pubblicazioni

NomeMETHODS IN MOLECULAR BIOLOGY

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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