Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 00037-2017- |
| Numero di pagine | 0 |
| Rivista | ERS Monograph |
| Volume | 3 |
| Stato di pubblicazione | Published - 2017 |
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All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
Cita questo
Arterial stiffness in symptomatic smokers with normal lung function. / Benfante, Alida; Maida, Carlo Domenico; Tuttolomondo, Antonino; Scichilone, Nicola; Cirrincione, Anna; Vassallo, Valerio Angelo.
In: ERS Monograph, Vol. 3, 2017, pag. 00037-2017-.Risultato della ricerca: Article
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TY - JOUR
T1 - Arterial stiffness in symptomatic smokers with normal lung function
AU - Benfante, Alida
AU - Maida, Carlo Domenico
AU - Tuttolomondo, Antonino
AU - Scichilone, Nicola
AU - Cirrincione, Anna
AU - Vassallo, Valerio Angelo
PY - 2017
Y1 - 2017
N2 - Chronic obstructive pulmonary disease (COPD) is associated with cardiovascular morbidity and mortality. Arterial stiffness and endothelial dysfunction index are validated surrogate cardiovascular markers and are increased in subjects with COPD. We tested whether increased arterial stiffness and endothelial dysfunction occur in symptomatic smokers with no evidence of bronchial obstruction. Clinical and lung functional assessments were conducted in smoker subjects with chronic respiratory symptoms and in COPD patients. Pulse wave velocity (PWV), aortic augmentation index (AIx) and reactive hyperaemia index (RHI) were measured to estimate the cardiovascular risk. 48 smokers (male n=37, female n=11; mean age 70±8.4 years) were studied. Smokers with respiratory symptoms without bronchial obstruction (n=13) did not differ from COPD patients (n=35) in terms of mean±SD PWV (12±3.2 m·s−1 versus 14±3.8 m·s−1; p=0.10), aortic AIx (25.2±11.8% versus 24.8±9.7%, p=0.89) and RHI (1.66±1.49 versus 1.62±1.43; p=0.79). The current investigation shows that the cardiovascular risk occurs in smokers with respiratory symptoms in the absence of bronchial obstruction. These findings need to be confirmed in larger populations in order to inform the design of intensive preventive programmes.
AB - Chronic obstructive pulmonary disease (COPD) is associated with cardiovascular morbidity and mortality. Arterial stiffness and endothelial dysfunction index are validated surrogate cardiovascular markers and are increased in subjects with COPD. We tested whether increased arterial stiffness and endothelial dysfunction occur in symptomatic smokers with no evidence of bronchial obstruction. Clinical and lung functional assessments were conducted in smoker subjects with chronic respiratory symptoms and in COPD patients. Pulse wave velocity (PWV), aortic augmentation index (AIx) and reactive hyperaemia index (RHI) were measured to estimate the cardiovascular risk. 48 smokers (male n=37, female n=11; mean age 70±8.4 years) were studied. Smokers with respiratory symptoms without bronchial obstruction (n=13) did not differ from COPD patients (n=35) in terms of mean±SD PWV (12±3.2 m·s−1 versus 14±3.8 m·s−1; p=0.10), aortic AIx (25.2±11.8% versus 24.8±9.7%, p=0.89) and RHI (1.66±1.49 versus 1.62±1.43; p=0.79). The current investigation shows that the cardiovascular risk occurs in smokers with respiratory symptoms in the absence of bronchial obstruction. These findings need to be confirmed in larger populations in order to inform the design of intensive preventive programmes.
UR - http://hdl.handle.net/10447/339598
UR - http://openres.ersjournals.com/content/erjor/3/3/00037-2017.full.pdf
M3 - Article
VL - 3
SP - 00037-2017-
JO - ERS Monograph
JF - ERS Monograph
SN - 2312-508X
ER -