Approccio diagnostico non invasivo con tomografia computerizzata multidetettore a 40 strati per lo studio della malattia aterosclerotica coronarica

Salvatore Novo, Enrico Hoffmann, Egle Corrado, Oreste Fabio Triolo, Giuseppina Novo, Massimo Midiri, Giuseppe Runza, Francesca Gennaro, Giuseppe Runza, Salvatore Evola

Risultato della ricerca: Articlepeer review

1 Citazioni (Scopus)


Background. Multidetector computed tomography coronary angiography (MDCT-CA) is a non-invasivetechnique that clearly shows coronary anatomy and correctly identifies plaque location and morphology.In this study we assessed diagnostic accuracy of MDCT-CA in detectiong significant stenosisin patients with clinically relevant coronary tree disease.Methods. Fifty patients (38 males, 12 females, mean age 60.9 ± 9.2 years) with atypical chest pain,stable or unstable angina pectoris, or non-ST-elevation myocardial infarction underwent MDCT-CA(Brilliance 40, Philips Medical Systems, Cleveland, OH, USA) within 3 days before diagnostic conventionalcoronary angiography. Inclusion criteria were sinus rhythm, heart rate <70 b/min, and abilityto hold breath for more than 12 s. Exclusion criteria were known intolerance to contrast medium,serum creatinine >2 mg/dl, pregnancy, respiratory insufficiency, unstable clinical conditions, and severeheart failure. Beta-blockers were administered if heart rate was >70 b/min. To synchronize arrivalof the contrast bolus (Iomeron 400, Bracco, Milan) in the coronary arteries with the start of thescan the bolus-tracking technique was used. Diagnostic accuracy was evaluated per segment, per vessel,and per patient.Results. Mean heart rate during examination was 61.9 ± 6.2 b/min; 618 segments were evaluated.The assessment was impaired by respiratory artifacts only in 1 patient (2%). MDCT-CA showed goodsensitivity, specificity, and positive and negative predictive values in detecting significant coronaryartery stenosis (94, 94, 91, and 96% per segment; 91, 97, 95, and 92% per vessel; 100, 100, 100, and100% per-patient, respectively).Conclusions. Forty-slice MDCT-CA showed a good diagnostic capability in detecting significantcoronary artery stenosis in patients referred to our institution for suspected or known significantcoronary artery disease.
Lingua originaleEnglish
pagine (da-a)508-518
Numero di pagine11
RivistaGiornale Italiano di Cardiologia
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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