Epigenetic mechanisms play an important role in the regulation of cell type-specific gene activities, yet how epigeneticpatterns are established and maintained remains poorly understood. Recent studies have supported a roleof DNA sequences in recruitment of epigenetic regulators. Alignment-free methods have been applied to identifydistinct sequence features that are associated with epigenetic patterns and to predict epigenomic profiles. Here,we review recent advances in such applications, including the methods to map DNA sequence to feature space,sequence comparison and prediction models. Computational studies using these methods have provided importantinsights into the epigenetic regulatory mechanisms.
|Numero di pagine||12|
|Rivista||Briefings in Bioinformatics|
|Stato di pubblicazione||Published - 2014|
All Science Journal Classification (ASJC) codes