Application of tRNS to improve multiple sclerosis fatigue: a pilot, single-blind, sham-controlled study

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Abstract

We evaluated the effects of transcranial random noise stimulation (tRNS) on fatigue in 17 subjects with relapsing–remitting multiple sclerosis with low physical disability. Two different patient groups underwent real or sham stimulation for 10 days, targeting the primary motor cortex of the dominant side or contralateral to the most compromised limb. In the ‘real group’, beneficial effects were observed using the Modified Fatigue Impact Scale (p = 0.04; physical subscale: p = 0.03), the subscales ‘change in health’ (p = 0.006) and ‘role limitations due to physical problems’ (p = 0.001) of the Multiple Sclerosis Quality of Life-54, and by assessing the patient impression of perceived fatigue (p = 0.005).
Lingua originaleEnglish
pagine (da-a)795-799
Numero di pagine5
RivistaJournal of Neural Transmission
Volume126
Stato di pubblicazionePublished - 2019

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Multiple Sclerosis
Fatigue
Motor Cortex
Extremities
Quality of Life
Health
Transcranial Direct Current Stimulation

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cita questo

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title = "Application of tRNS to improve multiple sclerosis fatigue: a pilot, single-blind, sham-controlled study",
abstract = "We evaluated the effects of transcranial random noise stimulation (tRNS) on fatigue in 17 subjects with relapsing–remitting multiple sclerosis with low physical disability. Two different patient groups underwent real or sham stimulation for 10 days, targeting the primary motor cortex of the dominant side or contralateral to the most compromised limb. In the ‘real group’, beneficial effects were observed using the Modified Fatigue Impact Scale (p = 0.04; physical subscale: p = 0.03), the subscales ‘change in health’ (p = 0.006) and ‘role limitations due to physical problems’ (p = 0.001) of the Multiple Sclerosis Quality of Life-54, and by assessing the patient impression of perceived fatigue (p = 0.005).",
author = "Filippo Brighina and Giuseppe Salemi and Alessia Bianchi and Sabrina Realmuto and Brigida Fierro and Massimo Gangitano and Paolo Ragonese and Giuseppe Cosentino and Erika Portera and Giulia Vazzoler",
year = "2019",
language = "English",
volume = "126",
pages = "795--799",
journal = "Journal of Neural Transmission",
issn = "0300-9564",
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TY - JOUR

T1 - Application of tRNS to improve multiple sclerosis fatigue: a pilot, single-blind, sham-controlled study

AU - Brighina, Filippo

AU - Salemi, Giuseppe

AU - Bianchi, Alessia

AU - Realmuto, Sabrina

AU - Fierro, Brigida

AU - Gangitano, Massimo

AU - Ragonese, Paolo

AU - Cosentino, Giuseppe

AU - Portera, Erika

AU - Vazzoler, Giulia

PY - 2019

Y1 - 2019

N2 - We evaluated the effects of transcranial random noise stimulation (tRNS) on fatigue in 17 subjects with relapsing–remitting multiple sclerosis with low physical disability. Two different patient groups underwent real or sham stimulation for 10 days, targeting the primary motor cortex of the dominant side or contralateral to the most compromised limb. In the ‘real group’, beneficial effects were observed using the Modified Fatigue Impact Scale (p = 0.04; physical subscale: p = 0.03), the subscales ‘change in health’ (p = 0.006) and ‘role limitations due to physical problems’ (p = 0.001) of the Multiple Sclerosis Quality of Life-54, and by assessing the patient impression of perceived fatigue (p = 0.005).

AB - We evaluated the effects of transcranial random noise stimulation (tRNS) on fatigue in 17 subjects with relapsing–remitting multiple sclerosis with low physical disability. Two different patient groups underwent real or sham stimulation for 10 days, targeting the primary motor cortex of the dominant side or contralateral to the most compromised limb. In the ‘real group’, beneficial effects were observed using the Modified Fatigue Impact Scale (p = 0.04; physical subscale: p = 0.03), the subscales ‘change in health’ (p = 0.006) and ‘role limitations due to physical problems’ (p = 0.001) of the Multiple Sclerosis Quality of Life-54, and by assessing the patient impression of perceived fatigue (p = 0.005).

UR - http://hdl.handle.net/10447/362645

UR - https://link.springer.com/journal/702

M3 - Article

VL - 126

SP - 795

EP - 799

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

SN - 0300-9564

ER -