Apoptotic effect of a phytosterol-ingredient and its main phytosterol (β-sitosterol) in human cancer cell lines

Luisa Tesoriere, Guadalupe Garcia-Llatas, Antonio Cilla, Andrea Alvarez-Sala, Reyes Barberá, Alessandro Attanzio

Risultato della ricerca: Article

1 Citazione (Scopus)

Abstract

Dietary interventions may effectively control cancer development, with phytosterols (PS) being a class of cancer chemopreventive dietary phytochemicals. The present study, for the first time, evaluates the antiproliferative effects of a PS-ingredient used for the enrichment of several foods and its main PS, β-sitosterol, at physiological serum levels, in the most prevalent cancer cells in women (breast (MCF-7), colon (HCT116) and cervical (HeLa)). In all three cell lines, these compounds induced significant cell viability reduction without a clear time- and dose-dependent response. Moreover, all treatments produced apoptotic cell death with the induction of DNA fragmentation through the appearance of a sub-G1 cell population. Thus, the use of PS as functional ingredients in the development of PS-enriched foods could exert a potential preventive effect against human breast, colon and cervical cancer, although further in vivo studies are required to confirm our preclinical findings.
Lingua originaleEnglish
pagine (da-a)1-12-12
Numero di pagine12
RivistaInternational Journal of Food Sciences and Nutrition
Stato di pubblicazionePublished - 2018

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Phytosterols
sitosterols
phytosterols
ingredients
cell lines
Cell Line
Neoplasms
Fortified Food
enriched foods
food enrichment
neoplasms
uterine cervical neoplasms
DNA fragmentation
Phytochemicals
DNA Fragmentation
in vivo studies
colorectal neoplasms
Uterine Cervical Neoplasms
breast neoplasms
Colonic Neoplasms

All Science Journal Classification (ASJC) codes

  • Food Science

Cita questo

Apoptotic effect of a phytosterol-ingredient and its main phytosterol (β-sitosterol) in human cancer cell lines. / Tesoriere, Luisa; Garcia-Llatas, Guadalupe; Cilla, Antonio; Alvarez-Sala, Andrea; Barberá, Reyes; Attanzio, Alessandro.

In: International Journal of Food Sciences and Nutrition, 2018, pag. 1-12-12.

Risultato della ricerca: Article

Tesoriere, Luisa ; Garcia-Llatas, Guadalupe ; Cilla, Antonio ; Alvarez-Sala, Andrea ; Barberá, Reyes ; Attanzio, Alessandro. / Apoptotic effect of a phytosterol-ingredient and its main phytosterol (β-sitosterol) in human cancer cell lines. In: International Journal of Food Sciences and Nutrition. 2018 ; pagg. 1-12-12.
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AU - Tesoriere, Luisa

AU - Garcia-Llatas, Guadalupe

AU - Cilla, Antonio

AU - Alvarez-Sala, Andrea

AU - Barberá, Reyes

AU - Attanzio, Alessandro

PY - 2018

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N2 - Dietary interventions may effectively control cancer development, with phytosterols (PS) being a class of cancer chemopreventive dietary phytochemicals. The present study, for the first time, evaluates the antiproliferative effects of a PS-ingredient used for the enrichment of several foods and its main PS, β-sitosterol, at physiological serum levels, in the most prevalent cancer cells in women (breast (MCF-7), colon (HCT116) and cervical (HeLa)). In all three cell lines, these compounds induced significant cell viability reduction without a clear time- and dose-dependent response. Moreover, all treatments produced apoptotic cell death with the induction of DNA fragmentation through the appearance of a sub-G1 cell population. Thus, the use of PS as functional ingredients in the development of PS-enriched foods could exert a potential preventive effect against human breast, colon and cervical cancer, although further in vivo studies are required to confirm our preclinical findings.

AB - Dietary interventions may effectively control cancer development, with phytosterols (PS) being a class of cancer chemopreventive dietary phytochemicals. The present study, for the first time, evaluates the antiproliferative effects of a PS-ingredient used for the enrichment of several foods and its main PS, β-sitosterol, at physiological serum levels, in the most prevalent cancer cells in women (breast (MCF-7), colon (HCT116) and cervical (HeLa)). In all three cell lines, these compounds induced significant cell viability reduction without a clear time- and dose-dependent response. Moreover, all treatments produced apoptotic cell death with the induction of DNA fragmentation through the appearance of a sub-G1 cell population. Thus, the use of PS as functional ingredients in the development of PS-enriched foods could exert a potential preventive effect against human breast, colon and cervical cancer, although further in vivo studies are required to confirm our preclinical findings.

KW - Antiproliferation

KW - Food Science

KW - apoptosis

KW - breast cancer

KW - cervical cancer

KW - colon cancer

KW - plant sterols

UR - http://hdl.handle.net/10447/315963

M3 - Article

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JO - International Journal of Food Sciences and Nutrition

JF - International Journal of Food Sciences and Nutrition

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