Several lines of evidence showed that apoptosis rate of cumulus cells in oocytes derived by assistedreproductive technologies could be used as an indicator of fertilizing gamete quality. Aim of the studywas to investigate the effects of three different ovarian stimulation protocols on the biological and clinicaloutcome in hyporesponder patients. Collected data showed a higher significant rate of DNA fragmentationindex (DFI) in U group (patients treated with Highly Purified human Menopausal Gonadotrophin) than inP group (treated with recombinant human Follicle Stimulating Hormone (r-hFSH) combined withrecombinant human Luteinizing Hormone (r-hLH)). Both groups R (treated with r-hFSH alone) and Pshowed a significant increase in collected and fertilized oocytes number, embryo quality number. Thisstudy showed that combined r-hFSH/r-hLH therapy could represent the best pharmacological strategy forcontrolled ovarian stimulation and suggests to use DFI as a biomarker of ovarian function inhyporesponder patients.
Lingua originaleEnglish
pagine (da-a)51-56
Numero di pagine6
RivistaEuroMediterranean Biomedical Journal
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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