Apolipoprotein E genotypic frequencies among Down syndrome patients imply early unsuccessful aging for ApoE4 carriers

Giusi Irma Forte, Maria Piccione, Mario Giuffre, Giuseppina Candore, Domenico Lio, Giovanni Corsello, Letizia Scola, Calogero Caruso, Martina Chiappelli, Roberto Verna, Federico Licastro, Massimiliano M. Corsi, Antonino Crivello

Risultato della ricerca: Articlepeer review

7 Citazioni (Scopus)

Abstract

Down syndrome (DS) might be considered a model for unsuccessful and early aging, possibly accelerated for those who carry the APOE4 allele associated with common age-related diseases, e.g., Alzheimer's disease and a poor prognosis after acute myocardial infarction, causing lower ApoE4 frequencies among the very old in general populations. We compared ApoE genotypic frequencies found for healthy adults (n = 211, age < 40; n = 79, ages 70-79; n = 71, ages > 90) to those found for DS patients (n = 106, mean age 9 years), all living in western Sicily. We found that the frequency of the ApoE23 genotype increased with age among the healthy adults (8.5%, 6.4%, 19.7%; p = 0.024) while ApoE34 frequency decreased (16.1%, 12.6%, 4.1%; p = 0.012). DS patients had APOE34 genotypic frequencies very similar to those found in septuagenarians (9%; p = 0.005). Analyzing results according to surviving rate of persons with DS, an age-related reduction of ApoE3/4 genotype frequency was found comparing =5 years old to >5 years old DS subjects. These results highlight DS as a model to understand the role of APOE4 allele in unsuccessful ageing considering that a number of proinflammatory supernumerary genes (Cu/Zn superoxide dismutase, Ets-2 transcription factors, Down syndrome critical region 1, stress-inducible factor, interferon-alpha receptor and the amyloid precursor protein) are located on chromosome 21 and are implied in the pathologic processes of DS.
Lingua originaleEnglish
pagine (da-a)293-299
Numero di pagine7
RivistaRejuvenation Research
Volume10
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

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