Apolipoprotein E genotypic frequencies among Down syndrome patients imply early unsuccessful aging for ApoE4 carriers

Maria Piccione, Giusi Irma Forte, Giovanni Corsello, Giuseppina Candore, Calogero Caruso, Letizia Scola, Mario Giuffre, Domenico Lio, Martina Chiappelli, Roberto Verna, Federico Licastro, Massimiliano M. Corsi, Antonino Crivello

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Abstract

Down syndrome (DS) might be considered a model for unsuccessful and early aging, possibly accelerated for those who carry the APOE4 allele associated with common age-related diseases, e.g., Alzheimer's disease and a poor prognosis after acute myocardial infarction, causing lower ApoE4 frequencies among the very old in general populations. We compared ApoE genotypic frequencies found for healthy adults (n = 211, age < 40; n = 79, ages 70-79; n = 71, ages > 90) to those found for DS patients (n = 106, mean age 9 years), all living in western Sicily. We found that the frequency of the ApoE23 genotype increased with age among the healthy adults (8.5%, 6.4%, 19.7%; p = 0.024) while ApoE34 frequency decreased (16.1%, 12.6%, 4.1%; p = 0.012). DS patients had APOE34 genotypic frequencies very similar to those found in septuagenarians (9%; p = 0.005). Analyzing results according to surviving rate of persons with DS, an age-related reduction of ApoE3/4 genotype frequency was found comparing =5 years old to >5 years old DS subjects. These results highlight DS as a model to understand the role of APOE4 allele in unsuccessful ageing considering that a number of proinflammatory supernumerary genes (Cu/Zn superoxide dismutase, Ets-2 transcription factors, Down syndrome critical region 1, stress-inducible factor, interferon-alpha receptor and the amyloid precursor protein) are located on chromosome 21 and are implied in the pathologic processes of DS.
Lingua originaleEnglish
pagine (da-a)293-299
Numero di pagine7
RivistaRejuvenation Research
Volume10
Stato di pubblicazionePublished - 2007

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Apolipoprotein E4
Apolipoproteins E
Down Syndrome
Proto-Oncogene Proteins c-ets
Alleles
Interferon alpha-beta Receptor
Genotype
Apolipoprotein E3
Sicily
Chromosomes, Human, Pair 21
Amyloid beta-Protein Precursor
Pathologic Processes
Alzheimer Disease
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

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title = "Apolipoprotein E genotypic frequencies among Down syndrome patients imply early unsuccessful aging for ApoE4 carriers",
abstract = "Down syndrome (DS) might be considered a model for unsuccessful and early aging, possibly accelerated for those who carry the APOE4 allele associated with common age-related diseases, e.g., Alzheimer's disease and a poor prognosis after acute myocardial infarction, causing lower ApoE4 frequencies among the very old in general populations. We compared ApoE genotypic frequencies found for healthy adults (n = 211, age < 40; n = 79, ages 70-79; n = 71, ages > 90) to those found for DS patients (n = 106, mean age 9 years), all living in western Sicily. We found that the frequency of the ApoE23 genotype increased with age among the healthy adults (8.5{\%}, 6.4{\%}, 19.7{\%}; p = 0.024) while ApoE34 frequency decreased (16.1{\%}, 12.6{\%}, 4.1{\%}; p = 0.012). DS patients had APOE34 genotypic frequencies very similar to those found in septuagenarians (9{\%}; p = 0.005). Analyzing results according to surviving rate of persons with DS, an age-related reduction of ApoE3/4 genotype frequency was found comparing =5 years old to >5 years old DS subjects. These results highlight DS as a model to understand the role of APOE4 allele in unsuccessful ageing considering that a number of proinflammatory supernumerary genes (Cu/Zn superoxide dismutase, Ets-2 transcription factors, Down syndrome critical region 1, stress-inducible factor, interferon-alpha receptor and the amyloid precursor protein) are located on chromosome 21 and are implied in the pathologic processes of DS.",
keywords = "Down syndrome, aging, apolipoprotein E",
author = "Maria Piccione and Forte, {Giusi Irma} and Giovanni Corsello and Giuseppina Candore and Calogero Caruso and Letizia Scola and Mario Giuffre and Domenico Lio and Martina Chiappelli and Roberto Verna and Federico Licastro and Corsi, {Massimiliano M.} and Antonino Crivello",
year = "2007",
language = "English",
volume = "10",
pages = "293--299",
journal = "Rejuvenation Research",
issn = "1549-1684",
publisher = "Mary Ann Liebert Inc.",

}

TY - JOUR

T1 - Apolipoprotein E genotypic frequencies among Down syndrome patients imply early unsuccessful aging for ApoE4 carriers

AU - Piccione, Maria

AU - Forte, Giusi Irma

AU - Corsello, Giovanni

AU - Candore, Giuseppina

AU - Caruso, Calogero

AU - Scola, Letizia

AU - Giuffre, Mario

AU - Lio, Domenico

AU - Chiappelli, Martina

AU - Verna, Roberto

AU - Licastro, Federico

AU - Corsi, Massimiliano M.

AU - Crivello, Antonino

PY - 2007

Y1 - 2007

N2 - Down syndrome (DS) might be considered a model for unsuccessful and early aging, possibly accelerated for those who carry the APOE4 allele associated with common age-related diseases, e.g., Alzheimer's disease and a poor prognosis after acute myocardial infarction, causing lower ApoE4 frequencies among the very old in general populations. We compared ApoE genotypic frequencies found for healthy adults (n = 211, age < 40; n = 79, ages 70-79; n = 71, ages > 90) to those found for DS patients (n = 106, mean age 9 years), all living in western Sicily. We found that the frequency of the ApoE23 genotype increased with age among the healthy adults (8.5%, 6.4%, 19.7%; p = 0.024) while ApoE34 frequency decreased (16.1%, 12.6%, 4.1%; p = 0.012). DS patients had APOE34 genotypic frequencies very similar to those found in septuagenarians (9%; p = 0.005). Analyzing results according to surviving rate of persons with DS, an age-related reduction of ApoE3/4 genotype frequency was found comparing =5 years old to >5 years old DS subjects. These results highlight DS as a model to understand the role of APOE4 allele in unsuccessful ageing considering that a number of proinflammatory supernumerary genes (Cu/Zn superoxide dismutase, Ets-2 transcription factors, Down syndrome critical region 1, stress-inducible factor, interferon-alpha receptor and the amyloid precursor protein) are located on chromosome 21 and are implied in the pathologic processes of DS.

AB - Down syndrome (DS) might be considered a model for unsuccessful and early aging, possibly accelerated for those who carry the APOE4 allele associated with common age-related diseases, e.g., Alzheimer's disease and a poor prognosis after acute myocardial infarction, causing lower ApoE4 frequencies among the very old in general populations. We compared ApoE genotypic frequencies found for healthy adults (n = 211, age < 40; n = 79, ages 70-79; n = 71, ages > 90) to those found for DS patients (n = 106, mean age 9 years), all living in western Sicily. We found that the frequency of the ApoE23 genotype increased with age among the healthy adults (8.5%, 6.4%, 19.7%; p = 0.024) while ApoE34 frequency decreased (16.1%, 12.6%, 4.1%; p = 0.012). DS patients had APOE34 genotypic frequencies very similar to those found in septuagenarians (9%; p = 0.005). Analyzing results according to surviving rate of persons with DS, an age-related reduction of ApoE3/4 genotype frequency was found comparing =5 years old to >5 years old DS subjects. These results highlight DS as a model to understand the role of APOE4 allele in unsuccessful ageing considering that a number of proinflammatory supernumerary genes (Cu/Zn superoxide dismutase, Ets-2 transcription factors, Down syndrome critical region 1, stress-inducible factor, interferon-alpha receptor and the amyloid precursor protein) are located on chromosome 21 and are implied in the pathologic processes of DS.

KW - Down syndrome

KW - aging

KW - apolipoprotein E

UR - http://hdl.handle.net/10447/61372

M3 - Article

VL - 10

SP - 293

EP - 299

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

ER -