Antitumor mechanism of the essential oils from two succulent plants in multidrug resistance leukemia cell

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Abstract

Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis obtained by hydrodistillation and compared the chemical composition of its essential oil with that of Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of both species against acute myeloid leukemia on an in vitro model and its multidrug resistant variant involving NF-kappaB pathway. The essential oils of both species produced a significant decrease in many targets of NF-κB both at mRNA and protein levels. The results corroborate the idea that essential oils may be a good alternative to traditional drugs in the treatment of cancer, especially in drug resistant cancer.
Lingua originaleEnglish
pagine (da-a)124-
Numero di pagine16
RivistaPharmaceuticals
Volume12
Stato di pubblicazionePublished - 2019

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Multiple Drug Resistance
Volatile Oils
Leukemia
Drug Resistance
Neoplasms
Kalanchoe
NF-kappa B
Acute Myeloid Leukemia
Pharmaceutical Preparations
Gas Chromatography-Mass Spectrometry
Messenger RNA
Growth
Proteins

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science

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title = "Antitumor mechanism of the essential oils from two succulent plants in multidrug resistance leukemia cell",
abstract = "Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis obtained by hydrodistillation and compared the chemical composition of its essential oil with that of Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of both species against acute myeloid leukemia on an in vitro model and its multidrug resistant variant involving NF-kappaB pathway. The essential oils of both species produced a significant decrease in many targets of NF-κB both at mRNA and protein levels. The results corroborate the idea that essential oils may be a good alternative to traditional drugs in the treatment of cancer, especially in drug resistant cancer.",
author = "Manuela Labbozzetta and Paola Poma and Maurizio Sajeva and Pietro Zito and {Notarbartolo Di Villarosa}, Monica and Ramarosandratana, {Aro Vonjy} and Mccubrey, {James A.}",
year = "2019",
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journal = "Pharmaceuticals",
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T1 - Antitumor mechanism of the essential oils from two succulent plants in multidrug resistance leukemia cell

AU - Labbozzetta, Manuela

AU - Poma, Paola

AU - Sajeva, Maurizio

AU - Zito, Pietro

AU - Notarbartolo Di Villarosa, Monica

AU - Ramarosandratana, Aro Vonjy

AU - Mccubrey, James A.

PY - 2019

Y1 - 2019

N2 - Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis obtained by hydrodistillation and compared the chemical composition of its essential oil with that of Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of both species against acute myeloid leukemia on an in vitro model and its multidrug resistant variant involving NF-kappaB pathway. The essential oils of both species produced a significant decrease in many targets of NF-κB both at mRNA and protein levels. The results corroborate the idea that essential oils may be a good alternative to traditional drugs in the treatment of cancer, especially in drug resistant cancer.

AB - Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis obtained by hydrodistillation and compared the chemical composition of its essential oil with that of Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of both species against acute myeloid leukemia on an in vitro model and its multidrug resistant variant involving NF-kappaB pathway. The essential oils of both species produced a significant decrease in many targets of NF-κB both at mRNA and protein levels. The results corroborate the idea that essential oils may be a good alternative to traditional drugs in the treatment of cancer, especially in drug resistant cancer.

UR - http://hdl.handle.net/10447/367917

M3 - Article

VL - 12

SP - 124-

JO - Pharmaceuticals

JF - Pharmaceuticals

SN - 1424-8247

ER -