Abstract
Marrubium globosum ssp. libanoticum is a medicinal plant used in Lebanon to reduce pain and smooth muscle spasms.A chloroform extract obtained from M. globosum aerial parts reduced acetylcholine-induced contractions in the isolated mouse ileum. The purification of this extract identified, among 12 isolated labdane diterpenoids, four new compounds, named 13-epicyllenin A (4), 13,15-diepicyllenin A (5), marrulibacetal (9), and marrulactone (11). Their structures were determined by spectroscopic methods. Compound 9, which exerted antispasmodic activity, is likely the active ingredient of the extract. Preliminary structure-activity relationships for this class of compounds are suggested.
Lingua originale | English |
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pagine (da-a) | 1477-1481 |
Numero di pagine | 5 |
Rivista | Journal of Natural Products |
Volume | 72 |
Stato di pubblicazione | Published - 2009 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.1600.1602???
- ???subjectarea.asjc.1300.1313???
- ???subjectarea.asjc.3000.3004???
- ???subjectarea.asjc.3000.3003???
- ???subjectarea.asjc.3000.3002???
- ???subjectarea.asjc.2700.2707???
- ???subjectarea.asjc.1600.1605???