Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases.

Francesco Antonio Salzano, Antonio Damato, Albino Carrizzo, Maurizio Forte, Valentina Trimarco, Anna Maciag, Carmine Vecchione, Annibale A. Puca, Michelangelo Bartolo

Risultato della ricerca: Articlepeer review

128 Citazioni (Scopus)

Abstract

Resveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: a) the sources, the metabolism, and the bioavailability of resveratrol; b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and health-related use.
Lingua originaleEnglish
pagine (da-a)215-226
Numero di pagine12
RivistaFood and Chemical Toxicology
Volume61
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

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