Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases.

Francesco Antonio Salzano; Antonio Damato; Albino Carrizzo; Maurizio Forte; Valentina Trimarco; Anna Maciag; Carmine Vecchione; Annibale A. Puca; Michelangelo Bartolo

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases.

Francesco Antonio Salzano, Antonio Damato, Albino Carrizzo, Maurizio Forte, Valentina Trimarco, Anna Maciag, Carmine Vecchione, Annibale A. Puca, Michelangelo Bartolo

Discipline Chirurgiche, Oncologiche e Stomatologiche

Risultato della ricerca: Article › peer review

128 Citazioni (Scopus)

Abstract

Resveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: a) the sources, the metabolism, and the bioavailability of resveratrol; b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and health-related use.

Lingua originale	English
pagine (da-a)	215-226
Numero di pagine	12
Rivista	Food and Chemical Toxicology
Volume	61
Stato di pubblicazione	Published - 2013

All Science Journal Classification (ASJC) codes

Food Science
Toxicology

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Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases. / Salzano, Francesco Antonio; Damato, Antonio; Carrizzo, Albino; Forte, Maurizio; Trimarco, Valentina; Maciag, Anna; Vecchione, Carmine; Puca, Annibale A.; Bartolo, Michelangelo.

In: Food and Chemical Toxicology, Vol. 61, 2013, pag. 215-226.

Risultato della ricerca: Article › peer review

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AU - Trimarco, Valentina

AU - Maciag, Anna

AU - Vecchione, Carmine

AU - Puca, Annibale A.

AU - Bartolo, Michelangelo

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