The present work reports investigation on phenolic compounds, antioxidant activity and enzyme inhibitoryactivities (acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-amylase and α-glucosidase) of differentextracts from two Moroccan Asteraceae species; Bubonium imbricatum Cav. and Cladanthus arabicus (L.) Cass.B. imbricatum extracts contained the highest amounts of phenolics and flavonoids, and also exhibited higherantioxidant activity. In this species, the highest total phenolic (1611.13 ± 14.23 μmolGAE/gextract) and flavonoid(376.11 ± 8.22 μmolQE/gextract) contents were observed in aqueous-methanol extract obtained by maceration.Further, UHPLC–MS analysis of C. arabicus and B. imbricatum extracts revealed the presence of several flavonoids(diosmetin, luteolin, apigenin 7-glucoside, and apigenin) and phenolic acids (benzoic, protocatechuic,p-coumaric, gallic, vanillic, caffeic, ferulic and isochlorogenic acids). The antioxidant activity of the extractswas dependent of the extraction process and solvent used. Aqueous-methanol extract of B. imbricatumprepared by maceration showed the highest activity with DPPH, ABTS and FRAP tests (respectively:IC50 = 8.53 ± 0.38 μg/ml, 3461.8 ± 9.38 μmolTE/gextract and 3281.6 ± 47.43 μmolAAE/gextract). The resultsindicated that most of the tested extracts or essential oils exhibited activity towards the tested enzymes. Overall,the results obtained in this work indicated the two Moroccan species studied, particularly B. imbricatum,as valuable sources of natural agents beneficial for human health.
|Numero di pagine||7|
|Rivista||South African Journal of Botany|
|Stato di pubblicazione||Published - 2018|
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