ANTINFLAMMATORY EFFECT OF LEVORAG (THD) EMULGEL ON RADIATION PROCTOCOLITIS AROUND A COLO-ANAL ANASTOMOSIS: AN INNOVATIVE CASE REPORT

Giovanni Tomasello, Francesco Carini, Daniele Pironi, Chiara Eberspacher, Gianmarco Grimaldi, Rossella Palma, Stefano Pontone, Salvatore Sorrenti, Domenico Mascagni, Giuseppe La Torre, Anna M. Romani, Antonio Ciulla, Carola Maria Gagliardo

Risultato della ricerca: Letterpeer review

Abstract

Post-radiation proctitis (PRP) is one of most common complications after abdominal and pelvic radiotherapy for different malignancies. Chronic radiation proctitis (CRP) usually develops 90 days or more after radiation. The present study aimed to show the employmentof Levorag Emulgel® (THD S.p.A Correggio, Reggio-Emilia, Italy) as off-label topical treatment, by instillation, to resolve the acute phase of PRP around a coloanal anastomosis, in a patient undergone surgery for an adenocarcinoma of the low rectum, then treated with the Gatekeeper® methodic to resolve fecal incontinence as consequence of the first surgical rectal resection. In conclusion, we can affirm that our methodic could represent a novelty for the new concept of evidencebased medicine. At now, standardized guidelines about the management of PRP don’t exist,5 so that the employment of THD Levorag Emulgel® by topical instillation could be a good proposal to assess a standardized protocol.
Lingua originaleEnglish
pagine (da-a)1-2
Numero di pagine2
RivistaMinerva Chirurgica
Volume74
Stato di pubblicazionePublished - 2020

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