Antimicrobial peptides from echinoderms as antibiofilm agents: a natural strategy to combat bacterial infections

Risultato della ricerca: Articlepeer review

3 Citazioni (Scopus)

Abstract

Increased attention has been focused on marine invertebrates as a source of bioactive molecules for biomedical applications.Many bioactive molecules are part of the innate immune system. Some more recently isolated compounds, mainly from thesea urchin and the sea cucumber, are antimicrobial peptides (AMPs) active against Gram-positive and Gram-negativebacteria, and fungi. In this review we described the most recent studies on AMPs isolated from echinoderms. AMPs aresmall peptides (< 10 kDa) with cationic charge and amphipathic structure. Recently, it was demonstrated that in thecoelomocyte lysates of Paracentrotus lividus and Holothuria tubulosa, AMPs possess activity against staphylococcal andPseudomonas aeruginosa biofilms. The data shows a great potential for application of AMPs in biotechnology for developingnovel therapeutic agents that are either alternative or complementary to conventional antibiotic therapy to combat multiresistantpathogens.
Lingua originaleEnglish
pagine (da-a)312-321
Numero di pagine10
RivistaTHE ITALIAN JOURNAL OF ZOOLOGY
Volume81
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

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