Increased attention has been focused on marine invertebrates as a source of bioactive molecules for biomedical applications.Many bioactive molecules are part of the innate immune system. Some more recently isolated compounds, mainly from thesea urchin and the sea cucumber, are antimicrobial peptides (AMPs) active against Gram-positive and Gram-negativebacteria, and fungi. In this review we described the most recent studies on AMPs isolated from echinoderms. AMPs aresmall peptides (< 10 kDa) with cationic charge and amphipathic structure. Recently, it was demonstrated that in thecoelomocyte lysates of Paracentrotus lividus and Holothuria tubulosa, AMPs possess activity against staphylococcal andPseudomonas aeruginosa biofilms. The data shows a great potential for application of AMPs in biotechnology for developingnovel therapeutic agents that are either alternative or complementary to conventional antibiotic therapy to combat multiresistantpathogens.
|Numero di pagine||10|
|Rivista||THE ITALIAN JOURNAL OF ZOOLOGY|
|Stato di pubblicazione||Published - 2014|
All Science Journal Classification (ASJC) codes
- Animal Science and Zoology