ANTIMICROBIAL PEPTIDES FROM COELOMOCYTES CYTOSOL OF PARACENTROTUS LIVIDUS WITH PHARMACEUTICAL POTENTIAL AS ANTI-STAPHYLOCOCCI BIOFILM AGENTS

Risultato della ricerca: Other

Abstract

Aims: To evaluate the anti-biofilm activity of the commercially available essentialoils from two Boswellia species.Methods and Results: The susceptibility of staphylococcal and Candida albicansbiofilms was determined by methyltiazotetrazolium (MTT) staining. At concentrationsranging from 217Æ3 lg ml)1 (25% v ⁄ v) to 6Æ8 lg ml)1 (0Æ75% v ⁄ v),the essential oil of Boswellia papyrifera showed considerable activity againstboth Staphylococcus epidermidis DSM 3269 and Staphylococcus aureus ATCC29213 biofilms. The anti-microbial efficacy of this oil against S. epidermidisRP62A biofilms was also tested using live ⁄ dead staining in combination withfluorescence microscopy, and we observed that the essential oil of B. papyriferashowed an evident anti-biofilm effect and a prevention of adhesion at sub-MICconcentrations. Boswellia rivae essential oil was very active against preformedC. albicans ATCC 10231 biofilms and inhibited the formation of C. albicansbiofilms at a sub-MIC concentration.Conclusions: Essential oils of Boswellia spp. could effectively inhibit the growthof biofilms of medical relevance.Significance and Impact of the Study: Boswellia spp. essential oils represent aninteresting source of anti-microbial agents in the development of new strategiesto prevent and treat biofilms.
Lingua originaleUndefined/Unknown
Pagine44-45
Stato di pubblicazionePublished - 2007

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